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| Product Name: | A-196 | | Synonyms: | A-196;6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine;SGC A-196;1-Phthalazinamine, 6,7-dichloro-N-cyclopentyl-4-(4-pyridinyl)-;6,7-Dichloro-N-cyclopentyl-4-(4-pyridinyl)-1-phthalazinamine;A-196
(A196;A-196;A 196;A196;A196,Histone Methyltransferase,A-196,Inhibitor,inhibit | | CAS: | 1982372-88-2 | | MF: | C18H16Cl2N4 | | MW: | 359.25 | | EINECS: | | | Product Categories: | | | Mol File: | 1982372-88-2.mol |  |
| | A-196 Chemical Properties |
| Boiling point | 584.6±45.0 °C(Predicted) | | density | 1.399±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 5 mg/ml) | | pka | 3.96±0.30(Predicted) | | form | powder | | color | white to light brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| RIDADR | UN 2811 6.1 / PGIII |
| | A-196 Usage And Synthesis |
| Description | A-196 is a selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that is more than 100-fold selective over other histone methyltransferases and non-epigenetic targets. A-196 has been shown to inhibit the di- and tri-methylation of lysine 20 of histone H4 (H4K20me) in multiple cell lines with IC50 values less than 1 μM. For more information on A-196 please visit the Structural Genomics Consortium (SGC). The negative control, SGC2043 (A-197), for A-196 is also available exclusively through the SGC. You can submit a request to receive the negative control here. | | Uses | A-196 is a potent inhibitor of SUV420H1. | | Biochem/physiol Actions | A-196 is a potent and selective chemical inhibitor of SUV420H1 and SUV420H2 that inhibits the di- and trimethylation of H4K20me in multiple cell lines. For full characterization details, please visit the A-196 probe summary on the Structural Genomics Consortium (SGC) website.SGC2043 is the negative control for the active probe, A-196. To request a sample of the negative control from the SGC, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc | | storage | Store at +4°C | | References | 1) Bromberg?et al.?(2017),?The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol.?13?317 |
| | A-196 Preparation Products And Raw materials |
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