ODM-201

ODM-201 Suppliers list
Company Name: Shenzhen Excellent Biotech Co., Ltd.
Tel: 13480692018
Email: ramyan@ex-biotech.com;sale@ex-biotech.com
Products Intro: Product Name:Darolutamide
CAS:1297538-32-9
Purity:99% Package:1KG;1USD Remarks:Large package please cotact us
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:ODM-201
CAS:1297538-32-9
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:1297538-32-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:ODM-201
CAS:1297538-32-9
Purity:As coa Package:As request Remarks:1297538-32-9
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: Product Name:ODM-201
CAS:1297538-32-9
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G

ODM-201 manufacturers

  • Darolutamide
  • $15.00-10.00 / KG
  • 2021-07-02
  • CAS:1297538-32-9
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Darolutamide
  • $1.00 / KG
  • 2021-04-16
  • CAS:1297538-32-9
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 5000KG

Related articles

  • Preparation of ODM-201
  • ODM-201 is a new generation AR inhibitor with superior preclinical efficacy compared to enzalutamide and bicalutamide, it does....
  • Nov 12,2019
ODM-201 Basic information
Product Name:ODM-201
Synonyms:CS-1565;ODM-201(Darolutamide);N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide;0DM021;BAY-1841788;ODM-021;0DM021;ODM 021;ODM 021;ODM-021;ODM-201
CAS:1297538-32-9
MF:C19H19ClN6O2
MW:398.85
EINECS:829-313-8
Product Categories:API
Mol File:1297538-32-9.mol
ODM-201 Structure
ODM-201 Chemical Properties
Boiling point 719.5±60.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
pka11.10±0.10(Predicted)
Safety Information
MSDS Information
ODM-201 Usage And Synthesis
DescriptionODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the  testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
ReferencesMoilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.
Tag:ODM-201(1297538-32-9) Related Product Information
Defactinib ODM203 PF 04554878 hydrochloride