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| | 4-Chloro-6-fluoroquinoline Basic information | | Application |
| Product Name: | 4-Chloro-6-fluoroquinoline | | Synonyms: | BUTTPARK 20\09-07;4-CHLORO-6-FLUOROQUINOLINE;4-Chloro-6-fluoroquinoline ISO 9001：2015 REACH;Quinoline, 4-chloro-6-fluoro-;4-Chloro-6-fluoroquinoline >;4-CHLORO-6-FLUOROQUINOLINE(WX900022);EOS-62017;4-Chloro-6-fluoroquinoline | | CAS: | 391-77-5 | | MF: | C9H5ClFN | | MW: | 181.59 | | EINECS: | 672-838-0 | | Product Categories: | Quinoline&Isoquinoline | | Mol File: | 391-77-5.mol |  |
| | 4-Chloro-6-fluoroquinoline Chemical Properties |
| Melting point | 75.0 to 79.0 °C | | Boiling point | 259.9±20.0 °C(Predicted) | | density | 1.366±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | powder to crystal | | pka | 2.90±0.16(Predicted) | | color | White to Light yellow | | InChI | InChI=1S/C9H5ClFN/c10-8-3-4-12-9-2-1-6(11)5-7(8)9/h1-5H | | InChIKey | CKTQPWIDUQGUGG-UHFFFAOYSA-N | | SMILES | N1C2C(=CC(F)=CC=2)C(Cl)=CC=1 | | CAS DataBase Reference | 391-77-5(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-41-37/38 | | Safety Statements | 26-39 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 2933499090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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ALFA
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| | 4-Chloro-6-fluoroquinoline Usage And Synthesis |
| Application | 4-Chloro-6-fluoroquinoline is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis. | | Synthesis | General procedure for the synthesis of 4-chloro-6-fluoroquinoline from 6-fluoro-2,3-dihydroquinolin-4(1H)-one: 412.55 mL of phosphoryl chloride, 11.5 g of iodine, and 165.0 g of manganese dioxide were added to a four-necked flask fitted with a stirrer and heated under stirring to 50 °C. Subsequently, 660 mL of a dichloroethane solution containing 165.02 g of 6-fluoro-2,3-dihydroquinolin-4(1H)-one was slowly added dropwise. After completion of the dropwise addition, the reaction mixture was refluxed for 2 hours. After completion of the reaction, the dichloroethane solvent was removed by distillation under reduced pressure. The residue was neutralized to pH 5-6 with cold aqueous sodium bicarbonate and filtered. The filter cake was washed with water to neutral and finally dried under vacuum to give 154.22 g of light gray solid 4-chloro-6-fluoroquinoline in 85.0% yield. | | References | [1] Patent: CN106565602, 2017, A. Location in patent: Paragraph 0008; 0024; 0025; 0026; 0027 |
| | 4-Chloro-6-fluoroquinoline Preparation Products And Raw materials |
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