- 5-Nitrooxindole
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- $0.00 / 1KG
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2022-01-27
- CAS:20870-79-5
- Min. Order: 1KG
- Purity: 98.1%
- Supply Ability: 100 tons
- 5-NITROOXINDOLE
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- $7.00 / 1KG
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2019-09-02
- CAS:20870-79-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: JD 362
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| | 5-NITROOXINDOLE Basic information |
| | 5-NITROOXINDOLE Chemical Properties |
| Melting point | 233-236 °C | | Boiling point | 411.4±45.0 °C(Predicted) | | density | 1.449±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.61±0.20(Predicted) | | form | solid | | color | Beige | | InChI | 1S/C8H6N2O3/c11-8-4-5-3-6(10(12)13)1-2-7(5)9-8/h1-3H,4H2,(H,9,11) | | InChIKey | JQCGHRDKVZPCRO-UHFFFAOYSA-N | | SMILES | [O-][N+](=O)c1ccc2NC(=O)Cc2c1 | | CAS DataBase Reference | 20870-79-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-43 | | Safety Statements | 26-36/37 | | WGK Germany | 3 | | Hazard Note | Irritant/Keep Cold | | HS Code | 2933790090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| | 5-NITROOXINDOLE Usage And Synthesis |
| Uses | - Reactant for synthesis of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors
- Reactant for preparation of Aurora kinase inhibitors
- Reactant for synthesis of 3-substituted 2-indolinone RET inhibitors
- Reactant for synthesis of 4-azachromeno[2,3-b]indol-11(6H)-ones and derivatives as analogs of ellipticine
- Reactant for preparation of [18F]fluorobenzylidene-indolinone as possible tyrosine kinase inhibitor for PET tumor imaging
- Reactant for preparation of 3-substituted indolin-2-ones as neuroprotective and toxic agents
| | Synthesis | General procedure for the synthesis of 5-nitroindol-2-one from 2-indolone: 2-indolone (26 g) was dissolved in 100 mL of concentrated sulfuric acid at -15 °C and fuming nitric acid (8.4 mL) was added slowly and dropwise. The reaction temperature needs to be strictly controlled to ensure that it is maintained at -15 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes. Subsequently, the reaction solution was carefully poured into ice water and a yellow precipitate was immediately generated. The precipitate was separated by filtration and 34 g of 5-nitroindol-2-one was finally obtained in 98% yield. | | References | [1] Patent: US2005/256145, 2005, A1. Location in patent: Page/Page column 43
[2] Patent: US2005/256144, 2005, A1. Location in patent: Page/Page column 19
[3] Patent: US2010/75952, 2010, A1. Location in patent: Page/Page column 64
[4] Patent: EP2157093, 2010, A1. Location in patent: Page/Page column 61-62
[5] Patent: US6878733, 2005, B1. Location in patent: Page/Page column 169 |
| | 5-NITROOXINDOLE Preparation Products And Raw materials |
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