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| | N-Methyl-N-(trimethylsilyl)acetamide Basic information |
| | N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 37/39-16 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 10-21 | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29319090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Flam. Liq. 3 |
| | N-Methyl-N-(trimethylsilyl)acetamide Usage And Synthesis |
| Chemical Properties | clear light yellow liquid | | Uses |
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:
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Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
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Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
| | Reactions |
The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
| | General Description | N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC). | | reaction suitability | reagent type: derivatization reagent
reaction type: Silylations | | Purification Methods | N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] | | References |
[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.
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| | N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials |
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