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Methylparaben

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Products Intro: Product Name:Methylparaben
CAS:99-76-3
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Products Intro: Product Name:Methylparaben
CAS:99-76-3
Purity:99% Package:100g,500g,1kg,5kg,10kg
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Products Intro: CAS:99-76-3
Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:Methylparaben
CAS:99-76-3
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Products Intro: Product Name:Methylparaben
CAS:99-76-3
Purity:99% Package:100g/ bag, 2 kg/ bag, 25kg/ carton or as required Remarks:white crystalline powder

Lastest Price from Methylparaben manufacturers

  • Methylparaben
  • US $1.00 / KG
  • 2018-08-21
  • CAS:99-76-3
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
  • Methylparaben
  • US $110.00 / KG
  • 2018-07-27
  • CAS:99-76-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000kg
Methylparaben Basic information
Content analysis Toxicity Utilization limitation Chemical properties Application Preparation Category Toxic grading Acute toxicity Flammability hazard characteristics Storage Extinguishing agent
Product Name:Methylparaben
Synonyms:AKOS BBS-00004393;4-(methoxycarbonyl)phenol;4-HYDROXYBENZOIC ACID METHYL ESTER;4-HYDROXYBENZOIC ACID METYL ESTER;4-(carbomethoxy)phenol;METHYLIS PARAHYDROXYBENZOAS;METHYLPARABEN;Methyl parasept
CAS:99-76-3
MF:C8H8O3
MW:152.15
EINECS:202-785-7
Product Categories:API;Other APIs;Aromatic Esters;Antioxidant;Biochemistry;Cosmetics;-;Color Former & Related Compounds;Developer;Functional Materials;Aromatics
Mol File:99-76-3.mol
Methylparaben Structure
Methylparaben Chemical Properties
Melting point 125-128 °C(lit.)
Boiling point 298.6 °C
density 1,46g/cm
vapor pressure 0.000005 hPa (20 °C)
refractive index 1.4447 (estimate)
FEMA 2710 | METHYL P-HYDROXYBENZOATE
Fp 280°C
storage temp. 0-6°C
solubility ethanol: soluble0.1M, clear, colorless
form Crystalline Powder
pkapKa 8.15(H2O,t =20.0) (Uncertain)
color White to almost white
PH5.8 (H2O, 20°C) (saturated solution)
Water Solubility Slightly soluble in water.
FreezingPoint 131℃
Merck 14,6107
BRN 509801
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKeyLXCFILQKKLGQFO-UHFFFAOYSA-N
CAS DataBase Reference99-76-3(CAS DataBase Reference)
NIST Chemistry ReferenceBenzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA Substance Registry SystemBenzoic acid, 4-hydroxy-, methyl ester(99-76-3)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22-36
Safety Statements 26-36-24/25-39
RIDADR UN 2769
WGK Germany 1
RTECS DH2450000
Autoignition Temperature>600 °C
TSCA Yes
HS Code 29182930
Hazardous Substances Data99-76-3(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 2100 mg/kg
MSDS Information
ProviderLanguage
4-Hydroxybenzoic acid methyl ester English
SigmaAldrich English
ACROS English
ALFA English
Methylparaben Usage And Synthesis
Content analysisMethod one: determinate according to the content analysis method in "butyl p-hydroxybenzoate (07002)". Per mL 1 mol/L sodium hydroxide is equivalent to the product (C8H8O3) 152.2mg.
Method two: Take 0.1 g (accurate to 1 mg) of the sample previously dried on silica gel for 5 h and move into a 300 ml flask with a glass plug. Plus l mol/L sodium hydroxide 10ml, heated in the water bath for 15min. After cooling, add 0.1mol/L potassium bromate 0.00ml, potassium bromide 5.0g and l mol/L hydrochloric acid 30ml. Put 15min in the dark room after sealing. Add potassium iodide 1 g, shake the flask vigorously, with 0.1mol/L sodium thiosulfate titration, with starch test solution (TS-235) as an indicator. Per ml 0.1mol/L potassium bromate is equivalent to the product (C8H8O3) 25.36mg.
ToxicityADI 0~10mg/kg(FAO/WHO,2001).
GRAS(FDA,§184.1490,2000).
LD503000mg/kg(Dog, mouth)
Utilization limitationFAO/WHO (1984): Jam, jelly, 1000mg/kg (single or with benzoate, sorbic acid and potassium sorbate).
EEC(1990,mg/kg): For use in pigment solutions, flavor syrups, coffee extracts, frozen drinks, fruit, glucose and soft drinks, pickled fish, salad, sauce, snack food, concentrated soup and so on, limited to GMP; Beer 70; Snack cereals and soup concentrate 175, the same as "07018 p-hydroxybenzoate".
HACSG is listed as a restricted list.
FDA,§184.1490(2000):0.1%.
Chemical propertiesWhite needle crystal; Slightly soluble in water, easily soluble in ethanol, ether, acetone and other organic solvents.
Application
  • Antioxidants.
  • Antimicrobial agents for medicine and organic synthesis.
  • Anti-mildew in food, cosmetics and pharmaceutical industries.
  • As a preservative antiseptic agents in the pharmaceutical industry, also for organic synthesis and food, spices, film and other preservative additives.
  • Similar products produced by similar production methods, like ethyl p-hydroxybenzoate (paraben B) and propyl p-hydroxybenzoate (Nepalese c), are also disinfectant preservatives.The products are irritating to the skin.
PreparationThe drug is esterified with p-hydroxybenzoic acid and methanol. The p-hydroxybenzoic acid was added to excess methanol to dissolve, stirring and adding concentrated sulfuric acid slowly. After heating and refluxing 10h, pour into the water to precipitate crystallization, then washed with water, sodium carbonate solution and water, finally obtain the crude product. Recrystallize from water or 25% ethanol to obtain finished product. The yield was 85%. Raw material consumption (kg/t): p-hydroxybenzoic acid 1200, methanol 1000.
CategoryToxic Chemicals
Toxic gradingModerate toxicity
Acute toxicityAbdomen-mouse LD50: 960 mg/kg
Flammability hazard characteristicsCombustible, excretes spicy smoke from fireground
StorageVentilated , low temperature and dry warehouse.
Extinguishing agentWater, carbon dioxide, dry powder, sand.
Chemical PropertiesColorless crystals or white, crystallinepowder; odorless or faint characteristic odor; slightburning taste. Soluble in alcohol,ether; slightly soluble in water, benzene, and carbontetrachloride.
Chemical PropertiesMethylparaben occurs as colorless crystals or a white crystalline powder. It is odorless or almost odorless and has a slight burning taste.
UsesIt is used as preservative in foods, beverages and cosmetics.
Usesparabens is one of the most commonly used group of preservatives in the cosmetic, pharmaceutical, and food industries. Parabens provide bacteriostatic and fungistatic activity against a diverse number of organisms, and are considered safe for use in cosmetics, particularly in light of their low sensitizing potential. An evaluation of preservatives for use in leave-on cosmetic preparations lists parabens among the least sensitizing. The range of concentrations used in cosmetics varies between 0.03 and 0.30 percent, depending on the conditions for use and the product to which the paraben is added.
UsesMethylparaben is an antimicrobial agent which is a white free-flowing powder. it is active against yeast and molds over a wide ph range. see parabens.
DefinitionChEBI: A 4-hydroxybenzoate ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with methanol. It is the most frequently used antimicrobial preservative in cosmetics. It occurs naturally in several fruits, particularly in blu berries.
UsesAs preservative in foods, beverages and cosmetics.
Production MethodsMethylparaben is prepared by the esterification of p-hydroxybenzoic acid with methanol.
HazardToxic. Use in foods restricted to 0.1%.
Pharmaceutical ApplicationsMethylparaben is widely used as an antimicrobial preservative in cosmetics, food products, and pharmaceutical formulations; see Table I. It may be used either alone or in combination with other methylparaben is the most frequently used antimicrobial preservative.
The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Antimicrobial activity increases as the chain length of the alkyl moiety is increased, but aqueous solubility decreases; therefore a mixture of parabens is frequently used to provide effective preservation. Preservative efficacy is also improved by the addition of propylene glycol (2–5%), or by using parabens in combination with other antimicrobial agents such as imidurea;
Owing to the poor solubility of the parabens, paraben salts (particularly the sodium salt) are more frequently used in formulations. However, this raises the pH of poorly buffered formulations.
Methylparaben (0.18%) together with propylparaben (0.02%) has been used for the preservation of various parenteral pharmaceutical formulations;
Contact allergensThis substance is one of the parabens family. Parabens are esters formed by p-hydroxybenzoic acid and an alcohol. They are largely used as biocides in cosmetics and toiletries, medicaments, or food. They have synergistic power with other biocides. Parabens can induce allergic contact dermatitis, mainly in chronic dermatitis and wounded skin.
SafetyMethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics and oral and topical pharmaceutical formulations. Although parabens have also been used as preservatives in injections and ophthalmic preparations, they are now generally regarded as being unsuitable for these types of formulations owing to the irritant potential of the parabens. These experiences may depend on immune responses to enzymatically formed metabolites of the parabens in the skin.
Parabens are nonmutagenic, nonteratogenic, and noncarcinogenic. Sensitization to the parabens is rare, and these compounds do not exhibit significant levels of photocontact sensitization or phototoxicity.
Hypersensitivity reactions to parabens, generally of the delayed type and appearing as contact dermatitis, have been reported. However, given the widespread use of parabens as preservatives, such reactions are relatively uncommon; the classification of overstated. Immediate hypersensitivity reactions following injection of preparations containing parabens have also been reported.
Delayed-contact dermatitis occurs more frequently when parabens are used topically, but has also been reported to occur after oral administration.
Unexpectedly, preparations containing parabens may be used by patients who have reacted previously with contact dermatitis provided they are applied to another, unaffected, site. This has been termed the paraben paradox.
Concern has been expressed over the use of methylparaben in infant parenteral products because bilirubin binding may be affected, which is potentially hazardous in hyperbilirubinemic neonates.
The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg bodyweight.
LD50 (dog, oral): 3.0 g/kg
LD50 (mouse, IP): 0.96 g/kg
LD50 (mouse, SC): 1.20 g/kg
storage Aqueous solutions of methylparaben at pH 3–6 may be sterilized by autoclaving at 120°C for 20 minutes, without decomposition. Aqueous solutions at pH 3–6 are stable (less than 10% decomposition) for up to about 4 years at room temperature, while aqueous solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days storage at room temperature);
Methylparaben should be stored in a well-closed container in a cool, dry place.
Purification MethodsFractionally crystallise the ester from its melt, and recrystallise it from *benzene, then from *benzene/MeOH and dry it over CaCl2 in a vacuum desiccator. [Beilstein 10 IV 360.]
IncompatibilitiesThe antimicrobial activity of methylparaben and other parabens is considerably reduced in the presence of nonionic surfactants, such as polysorbate 80, as a result of micellization.However, propylene glycol (10%) has been shown to potentiate the antimicrobial activity of the parabens in the presence of nonionic surfactants and prevents the interaction between methylparaben and polysorbate 80.
Incompatibilities with other substances, such as bentonite, magnesium trisilicate,talc,tragacanth,sodium alginate, essential oils,sorbitol,and atropine,have been reported. It also reacts with various sugars and related sugar alcohols. Absorption of methylparaben by plastics has also been reported; the amount absorbed is dependent upon the type of plastic and the vehicle. It has been claimed that low-density and high-density polyethylene bottles do not absorb methylparaben.
Methylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids.
Regulatory StatusMethylparaben and propylparaben are affirmed GRAS Direct Food Substances in the USA at levels up to 0.1%. All esters except the benzyl ester are allowed for injection in Japan. In cosmetics, the EU and Brazil allow use of each paraben at 0.4%, but the total of all parabens may not exceed 0.8%. The upper limit in Japan is 1.0%.
Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; inhalation preparations; ophthalmic preparations; oral capsules, tablets, solutions and suspensions; otic, rectal, topical, and vaginal preparations). Included in medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Tag:Methylparaben(99-76-3) Related Product Information
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