钩吻碱
中文名称 | 钩吻碱 |
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中文同义词 | 常绿黄素馨碱;钩吻素甲;钩吻碱钾;钩吻碱;胡曼鹼;钩吻素甲,钩吻碱钾,胡曼鹼,常绿黄素馨碱;钩吻素甲(标准品);钩吻碱(钩吻素甲,钩吻碱钾,胡曼鹼,常绿黄素馨碱) |
英文名称 | GELSEMINE |
英文同义词 | (3r-(3alpha,4abeta,5alpha,8alpha,8abeta,9s*,10s*))-5-ethenyl-3,4,4a,5,6,7,8,8a;[3R-(3alpha,4abeta,5alpha,8alpha,8abeta,9S*,10S*)]-5-Etheny l-3,4,4a,5,6,7,8,8a-octahydro-7-methylspiro[3,5,8-ethanylylidene-1H-p yrano[3,4-c]pyridine-10,3'-[3H]indol]-2'(1'H)-one;3h)indol)-2’(1’,h)-one;8abeta,9s*,10s*))-8alph;Gelsemin;ne,5-ethenyl-3,4,4a,5,6,7,8,8a-octahydro-7-methyl-,(3r-(3alpha,4abeta,5alpha,;-octahydro-7-methylspiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(;spiro(3,5,8-ethanylylidene-1h-pyrano(3,4-c)pyridine-10,3’-(3h)indol)-2’(1’h)-o |
CAS号 | 509-15-9 |
分子式 | C20H22N2O2 |
分子量 | 322.4 |
EINECS号 | 208-095-2 |
相关类别 | 植提标准品;对照品;中药对照品;标准品;植物提取物;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Alkaloids;标准品-中药标准品;新品;生物碱;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 509-15-9.mol |
结构式 |
钩吻碱 性质
熔点 | 181-183°C |
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比旋光度 | D20 +13° (c = 1.2 in chloroform) |
沸点 | 461.02°C (rough estimate) |
密度 | 1.1478 (rough estimate) |
折射率 | 1.5700 (estimate) |
储存条件 | 2-8°C |
溶解度 | 可溶于氯仿(少许)、甲醇(少许) |
酸度系数(pKa) | 7.75 in 80% methylcellosolve |
形态 | 粉末 |
颜色 | 白色 |
LogP | 3.080 (est) |
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%.
药理药效:具有兴奋中枢神经作用,但毒性很大。
安全信息
危险品标志 | T+ |
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危险类别码 | 23/24/25-26/27/28 |
安全说明 | 36/37/39-45-28 |
危险品运输编号 | UN 1544 6.1/PG 2 |
WGK Germany | 3 |
RTECS号 | LX9100000 |
危险等级 | 6.1(a) |
包装类别 | I |
毒害物质数据 | 509-15-9(Hazardous Substances Data) |
提供商 | 语言 |
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英文
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