| Company Name: |
Shanghai Boyle Chemical Co., Ltd.
|
| Tel: |
021-50182298 021-50180596 |
| Email: |
sales@boylechem.com |
| Products Intro: |
Product Name:10-PROPOXY-DECANOIC ACID
CAS:119290-12-9
|
| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:10-PROPOXY-DECANOIC ACID
CAS:119290-12-9
Purity:98% Package:1mg (solution); 5mg (solution); 10mg (solution) Remarks:Medbio
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:O-11;O11,O 11
CAS:119290-12-9
Purity:98% Package:25 mg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:O-11
CAS:119290-12-9
Purity:98% Package:1mg;5mg;10mg
|
|
| | 10-PROPOXY-DECANOIC ACID Basic information |
| Product Name: | 10-PROPOXY-DECANOIC ACID | | Synonyms: | 11-OXATETRADECANOIC ACID;10-PROPOXY-DECANOIC ACID;O-11;10-(propoxy)decanoyl-coenzyme A;HSRAJJQTYQHRSA-UHFFFAOYSA-N;Decanoic acid, 10-propoxy-;O11,O 11 | | CAS: | 119290-12-9 | | MF: | C13H26O3 | | MW: | 230.34 | | EINECS: | | | Product Categories: | | | Mol File: | 119290-12-9.mol |  |
| | 10-PROPOXY-DECANOIC ACID Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml |
| | 10-PROPOXY-DECANOIC ACID Usage And Synthesis |
| Definition | ChEBI: 10-propoxydecanoic acid is a medium-chain fatty acid. | | Biological Activity | O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killing Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50 of less than 1 μM in a cell culture assay.1,2 The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface glycoprotein (VSG), a protein critical for evading the host immune response.1 O-11 exhibits essentially no anti-fungal activity when assayed using C. neoformans, but does have a minor inhibitory effect on HIV-1 replication in T-lymphocytes.3 | | References | 1.Doering, T.L., Raper, J., Buxbaum, L.U., et al.An analog of myristic acid with selective toxicity for African trypanosomesScience2521851-1854(1991)
2.Doering, T.L., Lu, T., Werbovetz, K.A., et al.Toxicity of myristic acid analogs toward African trypanosomesProceedings of the National Academy of Sciences of the United States of America919735-9739(1994)
3.Langner, C.A., Lodge, J.K., Travis, S.J., et al.4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus IThe Journal of Biological Chemisty267(24)17159-17169(1992) |
| | 10-PROPOXY-DECANOIC ACID Preparation Products And Raw materials |
|