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化学名: | 5'-デオキシ-5-フルオロウリジン | 英語化学名: | Doxifluridine | 别名: | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione;1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone;Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine);5μdFUrd, Doxifluridine;5μdFUrd, 5-Fluoro-5μ-deoxyuridine;5’-Deoxy-5-fluomuridine;2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro- | CAS番号: | 3094-09-5 | 分子式: | C9H11FN2O5 | 分子量: | 246.19 | EINECS: | 221-440-1 | カテゴリ情報: | Heterocycles;API;Amines, Heterocycles, Metabolites & Impurities, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals;FURTULON;Anti-cancer&immunity;Pyridines, Pyrimidines, Purines and Pteredines;Pyrazines, Pyrimidines & Pyridazines;API intermediates;Bases & Related Reagents;Nucleotides;Intermediates & Fine Chemicals;Pharmaceuticals;Pyrazines, Pyrimidines & Pyridazines;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents | Mol File: | 3094-09-5.mol | |
融点 | 188-192 °C(lit.) | 比旋光度 | D25 +18.4° (c = 0.419 in water) | 比重(密度) | 1.3751 (estimate) | 屈折率 | 20 ° (C=1, H2O) | 貯蔵温度 | Inert atmosphere,Room Temperature | 溶解性 | DMSO (Slightly), Methanol (Slightly) | 外見 | Solid | 酸解離定数(Pka) | 7.4(at 25℃) | 色 | White | Merck | 14,3437 | CAS データベース | 3094-09-5(CAS DataBase Reference) |
主な危険性 | Xi | Rフレーズ | 36/37/38 | Sフレーズ | 26-36-24/25 | WGK Germany | 2 | RTECS 番号 | YU7526000 | Hazard Note | Irritant | 国連危険物分類 | IRRITANT, IRRITANT-HARMFUL | HSコード | 29349990 | 毒性 | LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu) |
| 5'-デオキシ-5-フルオロウリジン Usage And Synthesis |
外観 | 白色~微褐色の粉末又は結晶性粉末 | 用途 | 腫瘍組織で高い活性を有する
酵素:ピリミジンヌクレオシドホスホリラー
ゼによりフルオロウラシルに変換され、DNA
合成阻害作用を示します。 | 効能 | 抗悪性腫瘍薬, 代謝拮抗薬 | 商品名 | フルツロン (太陽ファルマ) | 説明 | Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is
more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers. | 化学的特性 | White Solid | Originator | Hoffmann-LaRoche (USA) | 使用 | antineoplastic, pyrimidine antimetabolite | 使用 | A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity | 使用 | An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine | 使用 | 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. | 定義 | ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro
racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase. | brand name | Furtulon | Biochem/physiol Actions | Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity. |
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