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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:AC-55649
CAS:59662-49-6
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；25 mg；5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
CAS:59662-49-6
Purity:98%HPLC Package:25KG;100USD
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:AC 55649
CAS:59662-49-6
Purity:97% Package:$96.9/10mg;$106.9/5mg;$346.9/50mg;$400.9/25mg;$1297.9/100mg;Bulk package Remarks:97%
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Email: sales@amadischem.com
Products Intro: Product Name:4-(4-octylphenyl)benzoic acid
CAS:59662-49-6
Purity:0.97 Package:mgs,gs,kgs Remarks:A832411
Company Name: ABCR GmbH & CO. KG
Tel: 49 721 95061 0
Email: info@abcr.de
Products Intro:
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Basic information
Product Name:4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID
Synonyms:4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID;4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID;8BCA;AC 55649;4-(4-Octylphenyl)-benzoic acid
CAS:59662-49-6
MF:C21H26O2
MW:310.43
EINECS:
Product Categories:Biphenyl & Diphenyl ether
Mol File:59662-49-6.mol
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Structure
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties
Melting point 148-152 °C(Solv: dichloromethane (75-09-2))
Boiling point 462.0±34.0 °C(Predicted)
density 1.037±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: >7mg/mL
form solid
pka4.23±0.10(Predicted)
Safety Information
WGK Germany 3
MSDS Information
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis
UsesAC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).
DefinitionChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.
Biological ActivityPotent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.
Biochem/physiol ActionsAC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.
4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials
Tag:4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID(59662-49-6) Related Product Information
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