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| | CLOFEZONE Basic information |
| | CLOFEZONE Chemical Properties |
| pka | pKa 4.5(H2O t unde?ned I unde?ned) (Uncertain) |
| | CLOFEZONE Usage And Synthesis |
| Originator | Perclusone,Anphar-Rolland,France,1967 | | Manufacturing Process | 935 g of phenylbutazone are dissolved, with heating to a lukewarm state, in
2.7 liters of acetone containing 20% water, and the mixture is filtered if
necessary. 853.5 g of p-chlorophenoxyacetic acid diethylamino ethylamide are
dissolved in 300 cc of acetone containing 20% water, and the solution is
poured into the phenylbutazone solution. There is slight heating, and the
solution clarifies. The salt crystallizes rapidly. Drying is effected on a Buchner
funnel and the mixture is washed in 450 cc of acetone containing 20% of
water. The 1,702 g of product obtained is recrystallized in 2,450 cc of acetone
containing 20% of water and, after drying in an oven at 37°C, 1,585 g (86%)
of product are obtained. The product is in the form of a white crystalline
powder having a melting point of from 87° to 89°C in the Maquenne block. | | Therapeutic Function | Analgesic, Antiinflammator |
| | CLOFEZONE Preparation Products And Raw materials |
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