5-(十四烷基氧)-2-糠酸
中文名称 | 5-(十四烷基氧)-2-糠酸 |
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中文同义词 | 5-(十四烷基氧)-2-糠酸;5-(十四烷氧基)-2-糠酸;乙酰辅酶A羧化酶-Α(ACCA)变构抑制剂(TOFA);化合物TOFA;5-(十四氧基)呋喃-2-甲酸;5-四巯基呋喃-2-羧酸(TOFA) |
英文名称 | 5-(TETRADECYLOXY)-2-FUROIC ACID |
英文同义词 | TOFA;5-(tetradecyloxy)-2-furancarboxylicaci;5-tetradecyloxy-2-furonicacid;mdl14514;RMI-14514;TOFA (5-(Tetradecyloxy)-2-furoic acid);5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID;5-(TETRADECYLOXY)-2-FUROIC ACID |
CAS号 | 54857-86-2 |
分子式 | C19H32O4 |
分子量 | 324.45 |
EINECS号 | |
相关类别 | 细胞生物学试剂;其它;对照品 |
Mol文件 | 54857-86-2.mol |
结构式 |
5-(十四烷基氧)-2-糠酸 性质
熔点 | 112-115 °C |
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沸点 | 441.7±25.0 °C(Predicted) |
密度 | 1.003±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:2.5 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 3.55±0.10(Predicted) |
颜色 | 白色至米色 |
稳定性 | 可在-20°下的DMSO或乙醇溶液保存长达1个月。 |
Target | Value |
ACCA
() |
TOFA (5-tetradecyloxy-2-furoic acid) is cytotoxic to lung cancer cells NCI-H460 and colon carcinoma cells HCT-8 and HCT-15, with an IC 50 at approximately 5.0, 5.0, and 4.5 μg/mL, respectively. TOFA at 1.0–20.0 μg/mL effectively blocks fatty acid synthesis and induces cell death in a dose-dependent manner. TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC 50 values of ~26.1 and 11.6 µg/mL, respectively. TOFA inhibits the proliferation of the cancer cells examined in a time and dose dependent manner, arrests the cells in the G0/G1 cell cycle phase and induces apoptosis. Acetyl-CoA-carboxylase-α (ACCA) is a key enzyme in the regulation of fatty acids synthesis. Inhibition of ACCA by TOFA decreases fatty acid synthesis and induces caspase activation and cell death in most PCa cell lines.
TOFA inhibits COC1/DDP cell growth in ovarian tumor mouse xenografts. The tumor growth rate is signifi¬cantly inhibited by TOFA compared with the DMSO treated control mice (1649±356.3 vs. 5128±390.4 mm 3 . No toxicity is observed in the heart, liver, spleen, lung, kidney and intestinal tissues. By inhibiting ACC, TOFA may be a promising small molecule agent for ovarian cancer therapy.
安全信息
WGK Germany | 2 |
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RTECS号 | LU0288000 |
海关编码 | 29321900 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101068 | TOFA | 1 mg | 250元 | |
2024/08/19 | HY-101068 | 5-(十四烷基氧)-2-糠酸 TOFA | 54857-86-2 | 5mg | 500元 |