| Company Name: |
INTATRADE GmbH |
| Tel: |
+49 3493/605464 |
| Email: |
sales@intatrade.de |
|
| | 3-(3-FLUOROPHENYL)PROPIONIC ACID Basic information |
| Product Name: | 3-(3-FLUOROPHENYL)PROPIONIC ACID | | Synonyms: | AKOS BC-2702;3-(3-FLUOROPHENYL)PROPRIONIC ACID;3-(3-FLUOROPHENYL)PROPIONIC ACID;BENZENEPROPANOIC ACID, 3-FLUORO-;ASINEX-REAG BAS 12820389;TIMTEC-BB SBB010231;3-Fluoro-benzenepropanoic acid;3-(3-Fluorophenyl)propionic acid, 3-Fluorohydrocinnamic acid | | CAS: | 458-45-7 | | MF: | C9H9FO2 | | MW: | 168.16 | | EINECS: | | | Product Categories: | Aromatic Propionic Acids | | Mol File: | 458-45-7.mol |  |
| | 3-(3-FLUOROPHENYL)PROPIONIC ACID Chemical Properties |
| Melting point | 43-47 °C(lit.) | | Boiling point | 125 °C10.5 mm Hg(lit.) | | density | 1.222±0.06 g/cm3(Predicted) | | Fp | 230 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | pka | 4.59±0.10(Predicted) | | color | White to Brown | | CAS DataBase Reference | 458-45-7(CAS DataBase Reference) |
| Hazard Codes | Xn,C | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-36 | | WGK Germany | 2 | | TSCA | TSCA listed | | HazardClass | CORROSIVE | | HS Code | 29163990 |
| | 3-(3-FLUOROPHENYL)PROPIONIC ACID Usage And Synthesis |
| Chemical Properties | White solid | | Synthesis | Step 1 (MZ-S1): trans-3-fluorocinnamic acid (20 g, 121.9 mmol) was hydrogenated in ethanol for 2 h under hydrogen atmosphere (7 psi) with 10% Pd/C (2 g) as catalyst. After completion of the reaction, the mixture was filtered through diatomaceous earth and washed with ethanol. The filtrate was concentrated under reduced pressure to give 19.5 g (97% yield) of MZ-S1 as an off-white solid, which could be used in subsequent steps without further purification. | | References | [1] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 91; 177
[2] Patent: US2004/39014, 2004, A1
[3] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 14, p. 1519 - 1522
[4] Patent: US5486541, 1996, A
[5] Patent: WO2008/85505, 2008, A1. Location in patent: Page/Page column 83-84 |
| | 3-(3-FLUOROPHENYL)PROPIONIC ACID Preparation Products And Raw materials |
|