| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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18930552037 |
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3bsc@sina.com |
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Product Name:PSB 10 hydrochloride;8-Ethyl-1,4,7,8-tetrahydro-4-Methyl-2-(2,3,5-trichlorophenyl)-5H-iMidazo[2,1-i]purin-5-oneMonohydrochloride
CAS:591771-91-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
EMMX Biotechnology LLC
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| Tel: |
888-539-0666 |
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info@emmx.com |
| Products Intro: |
Product Name:PSB 10 hydrochloride
CAS:591771-91-4
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
BOC Sciences
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info@bocsci.com |
| Products Intro: |
Product Name:PSB 10 hydrochloride
CAS:591771-91-4
Purity:≥98% by HPLC Remarks:PSB 10 is a potent and highly selective antagonist for the human adenosine A3 receptor that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and
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8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE manufacturers
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| | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE Basic information |
| Product Name: | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE | | Synonyms: | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE;PSB 10 HYDROCHLORIDE;PSB 10 | | CAS: | 591771-91-4 | | MF: | C16H14Cl3N5O.ClH | | MW: | 435.141 | | EINECS: | | | Product Categories: | | | Mol File: | 591771-91-4.mol | ![8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE Structure](CAS/GIF/591771-91-4.gif) |
| | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE Chemical Properties |
| storage temp. | Desiccate at +4°C | | solubility | Soluble to 25 mM in DMSO and to 10 mM in ethanol | | form | Powder |
| | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE Usage And Synthesis |
| Uses | PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice[1][2]. | | Biological Activity | Potent and highly selective antagonist for the human adenosine A 3 receptor, with low affinity for the rat A 3 receptor (K i values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A 1 , A 2A and A 2B receptors (K i values are 4.1, 3.3 and 30 μ M respectively) and > 1800-fold selectivity over rat A 1 and A 2A receptors. Acts as an inverse agonist in the [ 35 S]GTP γ S binding assay in hA 3 -CHO cells (IC 50 = 4 nM). Produces thermal hyperalgesia in mice in vivo . | | in vivo | PSB-10 hydrochloride (50-100 mg/kg; i.p.) dose-dependently decreases hot-plate response latencies in mice[2]. | | storage | Desiccate at +4°C | | References | [1] Ozola V, et, al. 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at Human A3 adenosine receptors. Bioorg Med Chem. 2003 Feb 6;11(3):347-56. DOI:10.1016/s0968-0896(02)00456-x
[2] Abo-Salem OM, et, al. Antinociceptive effects of novel A2B adenosine receptor antagonists. J Pharmacol Exp Ther. 2004 Jan;308(1):358-66. DOI:10.1124/jpet.103.056036 |
| | 8-ETHYL-1,4,7,8-TETRAHYDRO-4-METHYL-2-(2,3,5-TRICHLOROPHENYL)-5H-IMIDAZO[2,1-I]PURIN-5-ONE MONOHYDROCHLORIDE Preparation Products And Raw materials |
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