氟甲沙朵
| 中文名称 | 氟甲沙朵 |
|---|---|
| 中文同义词 | 氟甲沙朵;化合物 T11302 |
| 英文名称 | Flumexadol |
| 英文同义词 | Flumexadol;1841CERM;2-(α,α,α-Trifluoro-m-tolyl)morpholine;2-[3-(Trifluoromethyl)phenyl]morpholine;CERM-1841;Morpholine, 2-[3-(trifluoromethyl)phenyl]- |
| CAS号 | 30914-89-7 |
| 分子式 | C11H12F3NO |
| 分子量 | 231.21 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 30914-89-7.mol |
| 结构式 |  |
氟甲沙朵 性质
| 沸点 | 132 °C(Press: 10 Torr) |
|---|---|
| 密度 | 1.2081 (estimate) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（432.51 mM） |
| 酸度系数(pKa) | 8.41±0.40(Predicted) |
|
5-HT 2C Receptor 25 nM (Ki) |
In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-133024 | 氟甲沙朵 Flumexadol | 30914-89-7 | 5mg | 900元 |
| 2024/01/25 | HY-133024 | 氟甲沙朵 Flumexadol | 10 mM * 1 mLin DMSO | 990元 |