Flumexadol

Flumexadol Suppliers list
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:2-[3-(Trifluoromethyl)phenyl]morpholine
CAS:30914-89-7
Purity:0.99 Package:5KG;1KG Remarks:C11H12F3NO
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Flumexadol
CAS:30914-89-7
Purity:98.00% Package:10 mg;5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 15093356674;
Email: laboratory@coreychem.com
Products Intro: Product Name:Flumexadol
CAS:30914-89-7
Purity:Min98% HPLC/GC Package:1KG;8USD
Company Name: Aromsyn Co., Ltd.
Tel: +86-0571-85585865 +8613336024896
Email: CB@aromsyn.com
Products Intro: Product Name:2-(3-(Trifluoromethyl)phenyl)morpholine
CAS:30914-89-7
Purity:NLT 97% Package:1G;1KG;100KG Remarks:AS107113
Company Name: Jiangsu aikang biomedical research and development co., LTD  
Tel: 025-66110311 13155353615
Email: qzhang@aikonchem.com
Products Intro: Product Name:2-(3-(Trifluoromethyl)phenyl)morpholine
CAS:30914-89-7
Purity:95% HPLC or GC Package:10G,5G;1G
Flumexadol Basic information
Product Name:Flumexadol
Synonyms:Flumexadol;1841CERM;2-(α,α,α-Trifluoro-m-tolyl)morpholine;2-[3-(Trifluoromethyl)phenyl]morpholine;CERM-1841;Morpholine, 2-[3-(trifluoromethyl)phenyl]-
CAS:30914-89-7
MF:C11H12F3NO
MW:231.21
EINECS:
Product Categories:
Mol File:30914-89-7.mol
Flumexadol Structure
Flumexadol Chemical Properties
Boiling point 132 °C(Press: 10 Torr)
density 1.2081 (estimate)
storage temp. Store at -20°C
solubility DMSO: 100 mg/mL (432.51 mM)
pka8.41±0.40(Predicted)
Safety Information
MSDS Information
Flumexadol Usage And Synthesis
Biological ActivityFlumexadol is an orally active non-narcotic analgesic. It is a selective and affinity agonist of the 5-HT2C receptor with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, 40-fold more selective than the 5-HT2A receptor.
in vivo

In rats and dogs dosed with 14 C-Flumexadol (CERM1841), the 14 C is excreted in the urine. The 14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.

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target

5-HT 2C Receptor

25 nM (Ki)

Flumexadol Preparation Products And Raw materials
Tag:Flumexadol(30914-89-7) Related Product Information
Oxaflozane 4-(isopropyl)-2-[3-(trifluoromethyl)phenyl]morpholine hydrochloride 2-PHENYLMORPHOLINE 2-Amino-1-[3-(trifluoromethyl)phenyl]ethanol ALPHA-METHYL-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL 2-amino-1-(3-methylphenyl)ethanol Fludorex Flumexadol 4-TERT-BUTYL-2-[3-(TRIFLUOROMETHYL)PHENYL]-MORPHOLINE