| Company Name: |
Biolab Reagents |
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027-65279366 18108604356 |
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products@biolabreagent.com |
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| Product Name: | CTLA-4 | | Synonyms: | ANTI-IDDM12(N-TERMINAL) antibody produced in rabbit;CD152;CD152 (human): FC (human) (non-lytic);Rat Anti Mouse CTLA-4 (CD152);CTLA-4;CD_antigen=CD152;Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | monoclonal antibody;Elisa Kit-Mouse Elisa Kit | | Mol File: | Mol File | ![CTLA-4 Structure]() |
| | CTLA-4 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | color | white | | biological source | rabbit |
| WGK Germany | WGK 2 | | HS Code | 3504009000 | | Storage Class | 10 - Combustible liquids |
| | CTLA-4 Usage And Synthesis |
| Uses | CD152 (CTLA-4 (cytotoxic T-lymphocyte associated protein 4)) and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain.
CD152 and CD28 are both expressed on the cell surface as homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28. | | Biological Activity | CTLA4 (cytotoxic T-lymphocyte associated protein 4) or insulin dependent diabetes mellitus 12 (IDDM12) is responsible for inhibiting T-cell proliferation and facilitates T cell apoptosis. This protein is expressed post-antigen presentation and thus, is involved in immune and autoimmune disorders. It is implicated in the pathogenesis of various T cell mediated autoimmune disorders. |
| | CTLA-4 Preparation Products And Raw materials |
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