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| | FMoc-N-Me-Cys(Trt)-OH Basic information |
| Product Name: | FMoc-N-Me-Cys(Trt)-OH | | Synonyms: | N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-S-(triphenylmethyl)-L-cysteine;(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(tritylthio)propanoic acid;FMoc-N-Me-Cys(Trt)-OH;FMOC-N-METHYL-L-CYSTEINE(TRT);N-α-(9-Fluorenylmethoxycarbonyl)-N-α-methyl-S-trityl-L-cysteine;Fmoc-N-methyl-L-cysteine(Trityl);L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-S-(triphenylmethyl)-;FMOC-N-ME-CYS(TRT)-OH 1 G | | CAS: | 944797-51-7 | | MF: | C38H33NO4S | | MW: | 599.74 | | EINECS: | | | Product Categories: | amino acids | | Mol File: | 944797-51-7.mol |  |
| | FMoc-N-Me-Cys(Trt)-OH Chemical Properties |
| Melting point | 234-239°C | | Boiling point | 746.0±60.0 °C(Predicted) | | density | 1.260±0.06 g/cm3(Predicted) | | storage temp. | Store at -15°C to -25°C. | | pka | 3.72±0.10(Predicted) | | form | Solid | | color | White to off-white | | Optical Rotation | [α]22/D -25.0°, c = 0.5% in dichloromethane | | Major Application | peptide synthesis | | InChIKey | RAKOPMQMPUNRGI-DHUJRADRSA-N | | SMILES | C(O)(=O)[C@H](CSC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C |
| WGK Germany | 3 | | HS Code | 2930 90 16 | | Storage Class | 11 - Combustible Solids |
| | FMoc-N-Me-Cys(Trt)-OH Usage And Synthesis |
| Uses | Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A. | | Uses | Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A. | | reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| | FMoc-N-Me-Cys(Trt)-OH Preparation Products And Raw materials |
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