SB 203580盐酸盐 CAS#: 869185-85-3

SB 203580盐酸盐

生物活性靶点体外研究体内研究用途与合成方法 MSDS SB 203580盐酸盐价格(试剂级) 上下游产品信息

中文名称	SB 203580盐酸盐
中文同义词	化合物 T21675;SB 203580盐酸盐;化合物 SB 203580 HYDROCHLORIDE;4-(4-(4-氟苯基)-2-(4-(甲基亚磺酰基)苯基)-1H-咪唑-5-基)吡啶盐酸盐;SB 203580 HYDROCHLORIDE,P38 MAPK抑制剂;SB 203580 hydrochloride (RWJ 64809 hydrochloride;SB203580 hydrochloride;SB-203580 hydrochloride)
英文名称	SB 203580 (hydrochloride)
英文同义词	RWJ 64809 hydrochloride;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;RWJ 64809 HCl;SB203580 HCl;SB 203580 hydrochloride, p38 MAPK inhibitor
CAS号	869185-85-3
分子式	C21H17ClFN3OS
分子量	413.9
EINECS号
相关类别
Mol文件	869185-85-3.mol
结构式

SB 203580盐酸盐性质

储存条件	-20C
溶解度	不溶于乙醇；不溶于水； DMSO 中≥20.7 mg/mL
形态	亮黄色固体
颜色	浅黄至黄色
水溶解性	Soluble to 25 mM in water
稳定性	吸湿性
InChI	1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H
InChIKey	WOSGGXINSLMASH-UHFFFAOYSA-N
SMILES	Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl

SB 203580盐酸盐用途与合成方法

生物活性

SB 203580 hydrochloride (RWJ 64809 hydrochloride) 是一种选择性的，ATP 竞争性的 p38 MAPK 抑制剂，对 SAPK2a/p38 和 SAPK2b/p38β2 的 IC50 分别为 50 nM 和 500 nM。SB 203580 hydrochloride 抑制 LCK，GSK3β 和 PKBα，IC50 比 SAPK2a/p38 高 100-500 倍。SB 203580 hydrochloride 是一种自噬 (autophagy) 和有丝分裂 (mitophagy) 激活剂。

靶点

p38

50 nM (IC ₅₀ )

p38β2

500 nM (IC ₅₀ )

体外研究

SB 203580 (preincubated with 0-30 μM for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2) prevents the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC ₅₀ of 3-5 μM.
SB203580 blocks PKB phosphorylation (IC ₅₀ 3-5 μM). SB203580 inhibitsthe phosphorylation of Ser473 in a dose-dependent manner in both CT6 and activated human T cells and IL-2-responsive BA/F3 F7 B cells.

Cell Proliferation Assay

Cell Line:	CT6, BA/F3 cell line F7, and PBMC/T cells
Concentration:	0-30 μM
Incubation Time:	Preincubated with 0-30 μM SB203580 for 1 h and cultured for 24 h in the presence of 20 ng/mL IL-2
Result:	Prevented the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC ₅₀ of 3-5 μM.

Western Blot Analysis

Cell Line:	CT6 cells, activated human T cells, and BA/F3 F7 cells
Concentration:	0-30 μM
Incubation Time:	Preincubated with 0-30 μM SB203580 for 1 h before stimulating with 20 ng/mL IL-2 for 5 min
Result:	Inhibited the phosphorylation of PKB at Ser473 in a dose-dependent manner.

体内研究

SB203580 (5 mg/kg/day; intra peritoneal injected daily for 16 consecutive days, in female atymic Nu/Nu mice) treatment, p38WT tumors show a significantly smaller tumor burden when compared with p38TM tumors that were treated in parallel.

Animal Model:	Six-week-old female atymic Nu/Nu mice CAL27 p38WT and p38TM tumors
Dosage:	5 mg/kg/day
Administration:	Intra peritoneal injected daily for 16 consecutive days
Result:	After 2 weeks treatment, CAL27 p38WT tumors were significantly smaller; CAL27 p38TM tumors were not affected by the p38 inhibitor (n=10).

安全信息

WGK Germany	WGK 3
海关编码	2933399990
存储类别	11 - 可燃固体
危险性类别	急性毒性类别4 经口

MSDS信息

SB 203580盐酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/09/15	HY-10256AR	SB 203580盐酸盐 Adezmapimod hydrochloride (Standard)	869185-85-3	5 mg	990元
2026/09/15	HY-10256AR	SB 203580盐酸盐 Adezmapimod hydrochloride (Standard)	869185-85-3	10 mg	1485元

SB 203580盐酸盐