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NCE Biomedical Co.,Ltd. |
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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SPIRO PHARMA |
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eric_feng1954@126.com |
SB 203580 (hydrochloride) manufacturers
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| | SB 203580 (hydrochloride) Basic information |
| Product Name: | SB 203580 (hydrochloride) | | Synonyms: | RWJ 64809 hydrochloride;RWJ 64809 HYDROCHLORIDE;SB203580 HYDROCHLORIDE;SB-203580 HYDROCHLORIDE;SB 203580, Hydrochloride - CAS 869185-85-3 - Calbiochem;Adezmapimod (hydrochloride);Adezmapimod (SB-203580) hydrochloride;RWJ 64809 HCl;SB203580 HCl;SB 203580 hydrochloride, p38 MAPK inhibitor | | CAS: | 869185-85-3 | | MF: | C21H17ClFN3OS | | MW: | 413.9 | | EINECS: | | | Product Categories: | | | Mol File: | 869185-85-3.mol |  |
| | SB 203580 (hydrochloride) Chemical Properties |
| storage temp. | -20C | | solubility | insoluble in EtOH; insoluble in H2O; ≥20.7 mg/mL in DMSO | | form | Bright yellow solid | | color | Light yellow to yellow | | Water Solubility | Soluble to 25 mM in water | | Stability: | Hygroscopic | | InChI | 1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H | | InChIKey | WOSGGXINSLMASH-UHFFFAOYSA-N | | SMILES | Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl |
| WGK Germany | WGK 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | SB 203580 (hydrochloride) Usage And Synthesis |
| Uses | SB 203580 Hydrochloride is a protein kinase inhibitor. | | General Description | A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389). | | Biological Activity | sb203580 hcl is a specific inhibitor of p38-mapks with ic50 value of 0.6 μm [1].sb203580 is an inhibitor of p38-mapkα and p38-mapkβ. in neonatal myocytes, sb203580 prevented p38-mapk from activating mapkapk2 with ic50 value of 70 nm. it also significantly suppressed mapkapk2 activation in by il-1, osmotic stress or arsenite in kb cells. in neonatal rat ventricular myocytes, sb203580 inhibited jnk activity of activating c-jun with ic50 value of 3-10 μm. besides that, sb203580 affected the phosphorylation of small heat shock proteins caused by mapkapk2. it inhibited the il-1-, chemical- or osmotic stress-stimulated hsp27 phosphorylation with ic50 value of < 1μm in kb cells [1, 2]. | | Biochem/physiol Actions | Cell permeable: yes | | storage | Store at -20°C | | references | [1] cuenda a, rouse j, doza y n, et al. sb 203580 is a specific inhibitor of a map kinase homologue which is stimulated by cellular stresses and interleukin-1. febs letters, 1995, 364(2): 229-233.
[2] clerk a, sugden p h. the p38-mapk inhibitor, sb203580, inhibits cardiac stress-activated protein kinases/c-jun n-terminal kinases (sapks/jnks). febs letters, 1998, 426(1): 93-96. |
| | SB 203580 (hydrochloride) Preparation Products And Raw materials |
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