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Chlorambucil

Chlorambucil Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:4-[bis(2-chloroethyl)aminophenyl]butyric acid
CAS:305-03-3
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Chloroambucil
CAS:305-03-3
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:305-03-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Chloroambucil
CAS:305-03-3
Company Name: PI & PI BIOTECH INC.
Tel: 020-81716320
Email: Sales@pipitech.com
Products Intro: Product Name:Chlorambucil
CAS:305-03-3
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:4-[4-[Bis(2-chloroethyl)amino]phenyl]butanoic acid
Chlorambucil Basic information
Product Name:Chlorambucil
Synonyms:CHLORAMBUCIL;chloroambucil;4(p-bis(beta-chloroethyl)aminophenyl)butyricacid;4-[Bis(2-chioroethyl)amino]benzenebutanoicacid;Ambochlorin;Amboclorin;Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]-;Butanoic acid, 4-(bis(2-chloroethyl)amino)benzene-
CAS:305-03-3
MF:C14H19Cl2NO2
MW:304.21216
EINECS:206-162-0
Product Categories:LEUKERAN
Mol File:305-03-3.mol
Chlorambucil Structure
Chlorambucil Chemical Properties
Melting point 65-70 °C
density 1.2486 (rough estimate)
refractive index 1.6070 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent).
form neat
pkapKa ~1.3(H2O) (Uncertain)
Water Solubility <0.01 g/100 mL at 22 ºC
λmax588nm(DMSO aq.)(lit.)
Merck 14,2073
BRN 999011
Stability:Stable, but may be light sensitive. Store cold. Incompatible with strong oxidizing agents.
InChIKeyJCKYGMPEJWAADB-UHFFFAOYSA-N
CAS DataBase Reference305-03-3(CAS DataBase Reference)
NIST Chemistry ReferenceChlorambucil(305-03-3)
EPA Substance Registry SystemBenzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (305-03-3)
Safety Information
Hazard Codes T
Risk Statements 45-25-36/37/38
Safety Statements 53-26-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS ES7525000
HazardClass 6.1(b)
PackingGroup III
HS Code 29224999
Hazardous Substances Data305-03-3(Hazardous Substances Data)
ToxicityLD50 i.p. in rats: 58.2 mmole/kg (Ross)
MSDS Information
ProviderLanguage
Chloroambucil English
SigmaAldrich English
Chlorambucil Usage And Synthesis
Chemical Propertiesbeige powder
Chemical PropertiesChlorambucil is a crystalline solid
Usesantineoplastic, alkylating agent
UsesChlorambucil is a alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease.
UsesChlorambucil-d8 is the isotope labelled analogue of Chlorambucil (C324050), an alkylating agent that is used in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Ho dgkin's lymphoma (NHL) and Hodgkin's disease.
Usestranquilization aid
DefinitionChEBI: A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
IndicationsChlorambucil (Leukeran) is an aromatic nitrogen mustard that is intermediate in chemical reactivity between mechlorethamine and melphalan. Its mechanisms of action and range of antitumor activity are similar to theirs. It is well absorbed orally, but detailed information concerning its metabolic fate in humans is lacking.
Chlorambucil is used primarily as daily palliative therapy for chronic lymphocytic leukemia, Waldenstr?om’s macroglobulinemia, myeloma, and other lymphomas.
Bone marrow toxicity is the major side effect of chlorambucil. Nausea is uncommon or mild, and hair loss does not occur. Chlorambucil shares the immunosuppressive, teratogenic, and carcinogenic properties of the nitrogen mustards.
Brand nameLeukeran (GlaxoSmithKline.
General DescriptionWhite to pale beige crystalline or granular powder with a slight odor. Melting point 65-69°C.
General DescriptionChlorambucil is available as 2-mg tablets for oral administrationin the treatment of Hodgkin’s lymphoma, andchronic lymphocytic leukemia in combination with prednisoneand as a single agent. The mechanisms of resistanceare the same as those seen for other agents of the class suchas mechlorethamine. The agent is well absorbed (75%) uponoral administration and highly protein bound. Metabolism ismediated by CYP and occurs extensively to give severalmetabolites, including the active phenylacetic acid–nitrogenmustard. The drug is eliminated via the kidneys with a terminalelimination half-life of 1.5 hours. Adverse effects includedose-limiting myelosuppression, which are seen asboth leucopenia and thrombocytopenia. Nausea and vomitingoccur less often than for mechlorethamine. Additionaladverse effects include hyperuricemia, azoospermia, amenorrhea,seizures, pulmonary fibrosis, and skin rash.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileChloroambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds .
Fire HazardLiterature sources indicate that Chloroambucil is nonflammable.
Safety ProfileConfirmed carcinogen producing leukemia. Experimental carcinogenic and neoplastigenic data. Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: convulsions, cough, dyspnea, and interstitial fibrosis. Human reproductive effects by ingestion and possibly other routes: changes in spermatogenesis, menstrual cycle changes or disorders, and teratogenic effects of the fetal urogenital system. Experimental teratogenic and reproductive effects. Human mutation data reported. An anti-neoplastic agent. When heated to decomposition it emits very toxic fumes of Cland NOx.
Potential ExposureChlorambucil, an anticancer drug, is a derivative of nitrogen mustard. This drug is primarily used as an antineoplastic agent for treating lymphocytic leukemia; malignant lymphomas; follicular lymphoma; and Hodgkin’s disease. The treatments are not curative but do produce some marked remissions. Chlorambucil has also been tested for treatment of chronic hepatitis, rheumatoid arthritis; and as an insect chemosterilant. All of the chemical used in this country is imported from the United Kingdom. Work exposure in the United States would be limited to workers formulating the tablets, or to those patients receiving the drug.
Veterinary Drugs and TreatmentsChlorambucil may be useful in a variety of neoplastic diseases, including lymphocytic leukemia, multiple myeloma, polycythemia vera, macroglobulinemia, and ovarian adenocarcinoma. It may also be useful as adjunctive therapy for some immune-mediated conditions (e.g., glomerulonephritis, inflammatory bowel disease, nonerosive arthritis, or immune-mediated skin disease). It has found favor as a routine treatment for feline pemphigus foliaceous and severe feline eosinophilic granuloma complex due to the drug’s relative lack of toxicity in cats and efficacy.
CarcinogenicityChlorambucil is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsChlorambucil is recrystallised from pet ether (flat needles) and has a solubility at 20o of 66% in EtOH, 40% in CHCl3, 50% in Me2CO but is insoluble in H2O [Everett et al. J Chem Soc 2386 1953]. [Beilstein 14 IV 1715.] CARCINOGEN.
IncompatibilitiesMoisture. Chlorambucil is an alkylating agent. Reacts with proteins and a variety of nucleophilic compounds. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may beharmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur).
Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properlylabel and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator. Permanganate oxidation, high temperature incineration with scrubbing equipment, or microwave plasma treatment.
RegulationsConsumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act
Reportable quantity (RQ) = 10 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of chlorambucil = U035. Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
Chlorambucil is a prescription drug subject to labeling and other requirements.
Chlorambucil Preparation Products And Raw materials
Raw materialsPhosphorus oxychloride-->4-Phenylbutyric acid
Tag:Chlorambucil(305-03-3) Related Product Information
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