[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid manufacturers
|
| [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Basic information |
Product Name: | [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid | Synonyms: | MPEG5-OCH2COOH;[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;3,6,9,12,15,18-Hexaoxanonadecanoic acid;m-PEG6-CH4COOH;mPEG5-acetic acid;mPEG5-CH2COOH;2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid;3,6,9,12,15,18-Hexaoxa-nonadecansaeure | CAS: | 16142-03-3 | MF: | C13H26O8 | MW: | 310.34 | EINECS: | | Product Categories: | | Mol File: | 16142-03-3.mol | |
| [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Chemical Properties |
Boiling point | 418.6±40.0 °C(Predicted) | density | 1.124±0.06 g/cm3(Predicted) | pka | 3.39±0.10(Predicted) |
| [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Usage And Synthesis |
Description | m-PEG6-CH2COOH is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | Biological Activity | m-PEG5-CH2COOH is a non-cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | target | Non-cleavable < span> | PEGs | |
| [2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid Preparation Products And Raw materials |
|