M348

M348 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:ML-348
CAS:899713-86-1
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: +86-021-61551413 +8618813727289
Email: contact@trustwe.com
Products Intro: Product Name:ML348
CAS:899713-86-1
Purity:98% Package:Package as requetsed
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:M348
CAS:899713-86-1
Purity:95.0% windy 118
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:ML348
CAS:899713-86-1
Purity:99% Package:5KG;1KG Remarks:ML348
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:ML348
CAS:899713-86-1
Purity:98% Package:2mg Remarks:V2945
M348 Basic information
Product Name:M348
Synonyms:M348;ML348;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;CS-2370;ML-348 (ML348);GNF-Pf-1127;ML 348;GNF-PF-1127;1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
CAS:899713-86-1
MF:C18H17ClF3N3O3
MW:415.79
EINECS:809-791-4
Product Categories:
Mol File:899713-86-1.mol
M348 Structure
M348 Chemical Properties
Boiling point 546.2±50.0 °C(Predicted)
density 1.422±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form Powder
pka13.13±0.70(Predicted)
color White to off-white
Safety Information
MSDS Information
M348 Usage And Synthesis
UsesML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.
Biochem/physiol ActionsML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.
storageStore at +4°C
M348 Preparation Products And Raw materials
Tag:M348(899713-86-1) Related Product Information
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