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Alfa Aesar |
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- 2-Iodotoluene
-
- $120.00
-
2026-09-30
- CAS:615-37-2
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20 tons
- 2-Iodotoluene
-
- $100.00
-
2026-09-02
- CAS:615-37-2
- Min. Order: 1KG
- Purity: 99%
- 2-Iodotoluene
-
- $15.00
-
2021-07-13
- CAS:615-37-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
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| | 2-Iodotoluene Chemical Properties |
| Melting point | 11.27°C (estimate) | | Boiling point | 211 °C(lit.) | | density | 1.713 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.608(lit.) | | Fp | 194 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Liquid | | color | Clear yellow to orange | | Specific Gravity | 1.713 | | Sensitive | Light Sensitive | | BRN | 1634294 | | InChI | 1S/C7H7I/c1-6-4-2-3-5-7(6)8/h2-5H,1H3 | | InChIKey | RINOYHWVBUKAQE-UHFFFAOYSA-N | | SMILES | Cc1ccccc1I | | CAS DataBase Reference | 615-37-2(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1-iodo-2-methyl-(615-37-2) | | EPA Substance Registry System | Benzene, 1-iodo-2-methyl- (615-37-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37-36/37/39-27 | | RIDADR | UN 2810 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 29036990 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | 2-Iodotoluene Usage And Synthesis |
| Synthesis | Method 1,
0.2 mL of cuprous oxide/NH3 catalytic system, 135.8 mg of o-methylphenylboronic acid, 0.830 g of potassium iodide, and 2 mL of water were added to a round-bottom flask equipped with a magnetic stirrer. The system was left open at room temperature for 24 hours. After the reaction was complete, 1.5 mL of 2 mol/L sodium hydroxide solution was added, and the mixture was extracted three times with 2 mL of dichloromethane each time. The combined organic phases were concentrated to give 176 mg of 2-iodotoluene, with a yield of 81%. Method 2,
Accurately weigh o-bromotoluene (42.8 mg, 0.25 mmol), tetramethylammonium iodide (150.79 mg, 0.75 mmol), cuprous oxide (3.6 mg, 0.025 mmol), and L-proline (5.8 mg, 0.05 mmol), and add them sequentially to a 25 mL Schlenk flask. Add purified ethanol (1.5 mL) and react in a 110 °C oil bath for 30 h. After the reaction is complete, filter the reaction solution through a silica gel column into a 10 mL volumetric flask, and quantify the solution volume to the specified mark with ethyl acetate. Gas chromatography analysis showed that the yield of 2-iodotoluene was 28%. | | Chemical Properties | Liquid | | Uses | suzuki reaction | | Uses | 2-Iodotoluene is used as a reagent in the synthesis of aryl substituted quinones as β-secretase inhibitors. | | Definition | ChEBI: An iodoarene that is 2-methylbenzene substituted by an iodo group at position 1. |
| | 2-Iodotoluene Preparation Products And Raw materials |
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