| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Olvanil;N-VanillyloleoylaMide
CAS:58493-49-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:Olvanil
CAS:58493-49-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:Olvanil
CAS:58493-49-5
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
|
| | OLVANIL Basic information |
| Product Name: | OLVANIL | | Synonyms: | n-((4-hydroxy-3-methoxyphenyl)methyl)-9-octadecenamide(z)-;OLVANIL;NE-19550;N-VANILLYLOLEAMIDE;N-VANILLYLOLEOYLAMIDE;(n-vanillyl)-9-oleamide;N-VANILLYL-9-OCTADECENAMIDE;(N-Vanillyl)-9-oleamide, N-Vannilyloleoylamide | | CAS: | 58493-49-5 | | MF: | C26H43NO3 | | MW: | 417.62 | | EINECS: | | | Product Categories: | Vanilloid/TRPV channel | | Mol File: | 58493-49-5.mol |  |
| | OLVANIL Chemical Properties |
| Melting point | 36 °C | | Boiling point | 596.1±50.0 °C(Predicted) | | density | 0.982±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: <0.2mg/mL | | form | powder | | pka | 9.76±0.20(Predicted) | | color | white to off-white |
| WGK Germany | 3 | | RTECS | RG2242130 |
| | OLVANIL Usage And Synthesis |
| Description | Olvanil is a structural analog of capsaicin, which is the noxious active component of hot peppers of the Capsicum genus. It is the amide of vanillylamine and oleic acid. Olvanil acts as an agonist at the vanilloid receptor, VR1, inducing desensitization analgesia in rat and mouse models of pain. Olvanil has complex interactions with the cannabinoid system, in that it potentiates the agonist activity of endogenous cannabinoids by inhibiting the reuptake of arachidonyl ethanolamide (AEA). Olvanil is a more potent reuptake inhibitor than AM404, which is commonly used for this purpose (50% inhibition of reuptake at 10 μM versus 12% for AM404 at the same dose). Olvanil is also a CB1 agonist, but does not bind to CB2 receptors or inhibit fatty acid amide hydrolase. The overall activity of olvanil in most models is that of an analgesic, but it is unclear how these effects are mediated by VR1, the CB1 receptor, or other components of the endogenous pain sensation system. | | Uses | Analgesic. | | Uses | Olvanil is a TRPV1 agonist more potent than capsaicin. | | Definition | ChEBI: N-Vanillyloleamide is a member of methoxybenzenes and a member of phenols. | | Biological Activity | Potent vanilloid receptor agonist (pEC 50 values are 8.1 and 7.7 at rat and human VR1 receptors respectively). Also blocks anandamide uptake (IC 50 = 9 μ M) and may bind to CB 1 cannabinoid receptors. Antinociceptive following systemic administration. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ . | | storage | Desiccate at -20°C |
| | OLVANIL Preparation Products And Raw materials |
|