ENDOVION
| 中文名称 | ENDOVION |
|---|---|
| 中文同义词 | 1-(3,5-双(三氟甲基)苯基)-3-(4-溴-2-(2H-四唑-5-基)苯基)脲;化合物ENDOVION;化合物ENDOVION,10 MM DMSO 溶液 |
| 英文名称 | Endovion |
| 英文同义词 | Endovion;NS3728;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-;NS3728 >=98% (HPLC);1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;Endovion, 10 mM in DMSO;Endovion (NS 3728) |
| CAS号 | 265646-85-3 |
| 分子式 | C16H9BrF6N6O |
| 分子量 | 495.18 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 265646-85-3.mol |
| 结构式 |  |
ENDOVION 性质
| 密度 | 1.791±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 在 DMSO 中溶解度为 100 mM，在乙醇中溶解度为 50 mM |
| 酸度系数(pKa) | 3.95±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Water : < 0.1 mg/mL (insoluble) |
| InChI | 1S/C16H9BrF6N6O/c17-9-1-2-11(13-26-28-29-27-13)12(6-9)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29) |
| InChIKey | OQRAKHDEGGGWQO-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1cc(cc(c1)C(F)(F)F)NC(=O)Nc2c(ccc(c2)Br)c3n[nH]nn3 |
Endovion (NS3728) 是一种阴离子通道抑制剂 (如氯离子通道)，也是特异性的 VRAC/VSOAC 阻断剂。Endovion (NS3728) 还是一种 ANO1 抑制剂。
Chloride channel, VRAC/VSOAC.
ANO1.
Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, e.g., expression of p21
Waf1/Cip1
, Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.
Western Blot Analysis
| Cell Line: | Wild-type, resistant, and transiently transfected A2780 cells. |
| Concentration: | 10-100 μM. |
| Incubation Time: | 18 or 4.5 h. |
| Result: |
Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells.
Resulted in an increased LRRC8A protein expression. Significantly reduceed p53 and p21Waf1/Cip1 protein level in A2780WT cells. |
Cell Proliferation Assay
| Cell Line: | Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. |
| Concentration: | 10 μM. |
| Incubation Time: | 24 h. |
| Result: | Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-105917 | ENDOVION Endovion | 265646-85-3 | 5mg | 500元 |
| 2026/09/15 | HY-105917 | ENDOVION Endovion | 265646-85-3 | 10mM * 1mLin DMSO | 545元 |