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Calcium dobesilate

Calcium dobesilate Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: CAS:20123-80-2
Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:Calcium dobesilate
CAS:20123-80-2
Purity:98% Package:500g;1kg;5kg;10kg;100kg;1000kg... Remarks:pharmaceutical intermediates
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Products Intro: Product Name:Calcium dobesilate
CAS: 20123-80-2
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Products Intro: Product Name:calcium,2,5-dihydroxybenzenesulfonate
CAS:20123-80-2
Purity:0.99 Package:5KG;1KG
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
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Products Intro: Product Name:calcium,2,5-dihydroxybenzenesulfonate
CAS:20123-80-2
Purity:99% Package:5KG;1KG Remarks:C12H10CaO10S2

Calcium dobesilate manufacturers

  • Calcium dobesilate
  • $0.00 / Kg/Drum
  • 2022-01-12
  • CAS:20123-80-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000kg
  • Calcium Dobesilate
  • $10.00 / Kg/Bag
  • 2021-12-01
  • CAS:20123-80-2
  • Min. Order: 1Kg/Bag
  • Purity: 99%
  • Supply Ability: 20 Tons
  • Calcium dobesilate
  • $78.00 / KG
  • 2021-11-30
  • CAS:20123-80-2
  • Min. Order: 25KG
  • Purity: 98%
  • Supply Ability: 1-10mt
Calcium dobesilate Basic information
Product Name:Calcium dobesilate
Synonyms:CALCIUM DOBESILATE;Calcium Dobesilate Mnohydrate;CALIUM DOBESILATE MONOHYDRATE;CALCIUM DOBESILATE 1-HYDRATE;2,5-Dihydroxybenzenesulfonic acid, calcium salt;2,5-dihydroxy-benzenesulfonic aci calcium salt;dexium;doxium
CAS:20123-80-2
MF:2C6H5O5S.Ca
MW:418.41
EINECS:243-531-5
Product Categories:API
Mol File:20123-80-2.mol
Calcium dobesilate Structure
Calcium dobesilate Chemical Properties
Melting point >300° (dec)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: soluble15mg/mL, clear
form powder
color white to beige
InChIKeyQGNBTYAQAPLTMX-UHFFFAOYSA-L
CAS DataBase Reference20123-80-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
HazardClass IRRITANT
ToxicityLD50 in mice: 700 mg/kg (Esteve-Subirana)
MSDS Information
ProviderLanguage
Calcium dobesilate English
Calcium dobesilate Usage And Synthesis
DescriptionCalcium dobesilate is a vasoprotective. It is the calcium salt of dobesilic acid. It is a synthetic molecule with the ability to reduce capillary permeability in the body. In Switzerland the drug is sold by the pharmaceutical company OM Pharma under the trade name of Doxium in capsules containing 500 mg of active ingredient.
Calcium dobesilate is indicated in states of fragility and altered capillary permeability, e.g. diabetic retinopathy, chronic venous disease and hemorrhoidal disease. In combination with lidocaine or with lidocaine and dexamethasone, the drug enters the composition of preparations for the therapy of hemorrhoidal disease. In association with potassium hydrodex-sulfate[citation needed] enters the composition of adjuvant gels in the treatment of varicose veins. The efficacy of calcium dobesilate has been described in patients with microangiopathies such as diabetic retinopathy and diabetic nephropathy.
Chemical PropertiesWhite or almost white, hygroscopic powder.
OriginatorDoxium,Carrion,France,1971
UsesCalcium dobesilate is an antioxidant that has been used to treat diabetic retinopathy, in which it slows progression of the disease during long-term oral treatment by reducing microvascular permeability, leading to improved visual acuity. It not only acts as an antioxidant but also stimulates endothelial production of nitric oxide.
Uses
Dobesilate calcium has been used to study its interference in different in vitro assay systems for the determination of creatinine, uric acid, cholesterol, and triglycerides.
IndicationsCalcium dobesilate (CaD) is a widely prescribed veno-tonic drug for CVI, diabetic retinopathy, and the symptoms of hemorrhoid attacks.
Calcium dobesilate is also almost the only one angioprotective drug that recently remains the object of interest in treatment of diabetic retinopathy including clinical studies (Leal et al. 2010, Einarsdottir & Stefansson, 2009, Ribeiro et al., 2006), and even it was used as a standard for determination of the particular activity of a traditional Chinese herbal medicine preparation (Luo et al. 2009).
Manufacturing ProcessTo an ether solution of 108 grams 1,4-benzoquinone, maintained below 0°C, one adds an also very cold solution of 102 grams of pure calcium bisulfite as a 50% solution in distilled water. The addition is made carefully so as to maintain a very low temperature (0° to 4°C) in the vessel, and under stirring so as to mix the water and ether phase.
At the end of the addition, an almost colorless ether layer swims on the surface of the strongly colored water layer. After removal of the ether layer, the water layer is concentrated to dryness under vacuum and a stream of an inert gas. An earthy precipitate is formed, which after recrystallization yields 100 grams of hydroquinone calcium sulfonate, which decomposes without melting above 250°C.
The product consists of very small crystals having a powdery aspect and a pink color which deepens on contact with air. This product is very soluble in water and alcohol, and insoluble in ether.
Therapeutic FunctionVasodilator
General Description
Dobesilate calcium belongs to the family of fibroblast growth factor (FGF) inhibitors.
Biochem/physiol ActionsDobesilate Calcium is a vasoprotectant used as a treatment for chronic venous disease, diabetic retinopathy and other microvascular disorders. Its mechanism of action is not fully understood. It appears that dobesilate calcium increases endothelial nitric oxide levels by enhancing the activity of nitric oxide synthase and decreasing capillary hyperpermeability. Also in diabetic retinopathy dobesilate calcium prevents the blood-retinal barrier breakdown induced by diabetes by restoration of the tight junction protein, and decreasing the leukocyte adhesion to retinal vessels.
Side effectsFever
Skin reactions
Arthralgia(joint pain)
Gastrointestinal disorders
Agranulocytosis (lower white blood cell count)
Mode of actionCalcium dobesilate is a vaosactive drug used in the management of diabetic retinopathy and venous insufficiency. Calcium dobesilate's mechanism of action is thought to be related to decreasing tissue edema by altering vascular permeability and platelet aggregation. Mentes and colleagues randomized 29 patients with symptomatic hemorrhoids to calcium dobesilate and a high-fiber diet or to a highfiber diet alone. Eighty-six percent of patients treated with calcium dobesilate described cessation of bleeding and improvement in perianal irritation.
Calcium dobesilate Preparation Products And Raw materials
Raw materials1,4-Benzoquinone-->Calcium bisulfite
Tag:Calcium dobesilate(20123-80-2) Related Product Information
Fructose sodium diphosphate 4'-Hydroxy-4-biphenylcarbonitrile Potassium cyanate Calcium carbonate Calcium oxide Calcium chloride Dodecylbenzenesulphonic acid Benzenesulfonic acid Calcium formate Sulfanilic acid METHANESULFONIC ACID CALCIUM SALT Calcium dobesilate monohydrate Calcium dobesilate CALCIUM DODECYLBENZENE SULFONATE PHENOLSULFONIC ACID CALCIUM calcium sulfate Calcium Propionate