阿氯米松
中文名称 | 阿氯米松 |
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中文同义词 | 阿氯米松;化合物 T14154 |
英文名称 | Alclometasone |
英文同义词 | ALCLOMETHASONE DIPROPIONATE;7α-Chloro-16α-methylprednisolone;7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione;Alclometasone;Vaderm;(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione;AlcloMethasone;Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)- |
CAS号 | 67452-97-5 |
分子式 | C22H29ClO5 |
分子量 | 408.919 |
EINECS号 | |
相关类别 | 小分子药物;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids |
Mol文件 | 67452-97-5.mol |
结构式 |
阿氯米松 性质
熔点 | 176-179° |
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比旋光度 | D26 +47.5° (c = 0.3 in DMF) |
沸点 | 607.1±55.0 °C(Predicted) |
密度 | 1.34±0.1 g/cm3(Predicted) |
酸度系数(pKa) | 12.30±0.70(Predicted) |
Alclometasone (7a-Chloro-16a-methyl prednisolone) 是一种糖皮质激素 (glucocorticoid),可抑制白细胞促炎性介质的释放。Alclometasone 可用于缓解皮质类固醇反应性皮肤病,包括特应性皮炎,湿疹,牛皮癣和过敏性皮炎。
IC50: glucocorticoid receptor
The prodrug of alclometasone is alclometasone dipropionate.Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice.