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| | flumethiazide Basic information |
| Product Name: | flumethiazide | | Synonyms: | 6-Trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiazine 1,1-dioxide;Ademol;Fludemil;Routrax;Trifluoromethylthiazide;flumethiazide;NSC-44626;NSC44626 | | CAS: | 148-56-1 | | MF: | C8H6F3N3O4S2 | | MW: | 329.278 | | EINECS: | 2057174 | | Product Categories: | | | Mol File: | 148-56-1.mol |  |
| | flumethiazide Chemical Properties |
| Melting point | 306.6°C | | Boiling point | 560.0±60.0 °C(Predicted) | | density | 1.6578 (estimate) | | pka | pKa 6.3(H2O) (Uncertain) | | Water Solubility | 1.05g/L(room temperature) |
| | flumethiazide Usage And Synthesis |
| Originator | Ademol,Squibb,US,1959 | | Definition | ChEBI: Flumethiazide is a benzothiadiazine. | | Manufacturing Process | Chilled 3-trifluoromethylaniline (32.2 g) is added dropwise over a 45-minute
period to 150 ml of chlorosulfonic acid with stirring and cooling. The ice bath
is removed and 140 g of sodium chloride is added over 3 hours. The mixture
is heated on a water bath for 30 minutes, then gradually up to 160°C over 6
hours. The cooled reaction mixture is diluted with 500 ml of an ice water
slurry and taken into ether. The ether is dried and evaporated to leave 5-
trifluoromethylamine-2,4-disulfonyl chloride.
The crude residue is heated on the steam bath for 1 hour with 75 ml of
concentrated ammonium hydroxide. Cooling and filtration gives 2,4-
disulfamyl-5-trifluoromethylaniline, MP 241°C to 243°C.
This intermediate is treated with an excess of 98% formic acid at steam bath
temperature for 3 hours. Evaporation and dilution with water gives 7-sulfamyl-
6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide, MP 304°C to 308°C. | | Therapeutic Function | Carbonic anhydrase inhibitor |
| | flumethiazide Preparation Products And Raw materials |
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