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Punicalagin

Punicalagin Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:TIANFUCHEM--65995-63-3--High purity Punicalagin in stock
CAS:65995-63-3
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Punicalagin
CAS:65995-63-3
Purity:As coa Package:As request Remarks:65995-63-3
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Punicalagin
CAS:65995-63-3
Purity:HPLC>=98% Package:20mg
Company Name: Chengdu Greenpure Biopharma CO.,Ltd
Tel: 18283602253
Email: jancyzheng@gcgreenpure.com
Products Intro: Product Name:Punicalagin
CAS:65995-63-3
Purity:98% Package:5mg
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Punicalagin
CAS:65995-63-3
Purity:98% Package:1KG;2USD

Punicalagin manufacturers

  • Punicalagin
  • $0.00 / 20mg
  • 2020-05-11
  • CAS:65995-63-3
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
  • Punicalagin
  • $2.00 / 1KG
  • 2019-07-06
  • CAS:65995-63-3
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 10000kg

Related articles

Punicalagin Basic information
Description Antioxidant Activity
Product Name:Punicalagin
Synonyms:Punicalagin;PULCHINENOSIDE B4(RG);Punicalagin (98%);Punicalagin (40%);Punicalagins, 98%, from Punica granatum L.;Punicalagin - 98% min;Punicalagin - Technical;D-Glucose, cyclic 4,6-[(2S,2'S)-2,2'-(5,10-dihydro-2,3,7,8-tetrahydroxy-5,10-dioxo[1]benzopyrano[5,4,3-cde][1]benzopyran-1,6-diyl)bis[3,4,5-trihydroxybenzoate]] cyclic 2,3-[(1S)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate]
CAS:65995-63-3
MF:C48H28O30
MW:1084.72
EINECS:
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:65995-63-3.mol
Punicalagin Structure
Punicalagin Chemical Properties
Melting point >155°C (dec.)
density 2.076±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility methanol: soluble5mg/mL, clear
pka1.92±0.60(Predicted)
form powder
color faint yellow to dark yellow
Stability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
InChIKeyZJVUMAFASBFUBG-UYMKNUMKSA-N
Safety Information
Safety Statements 24/25
WGK Germany 3
HS Code 29389090
Hazardous Substances Data65995-63-3(Hazardous Substances Data)
MSDS Information
Punicalagin Usage And Synthesis
Description

Punicalagin is an ellagitannin, a type of phenolic compound. It is found in forms alpha and beta in pomegranates (Punica granatum), in Terminalia catappa and Terminalia myriocarpa, and in Combretum molle, the velvet bushwillow, a plant species found in South Africa. These three genera are all Myrtales and the last two are both Combretaceae.
Punicalagins are water-soluble and hydrolyze into smaller phenolic compounds, such as ellagic acid. There were no toxic effects in rats on a 6% diet of punicalagins for 37 days. In laboratory research, punicalagins had carbonic anhydrase inhibitor activity.

Antioxidant Activity

Punicalagins are large molecules (ellagitannins) found in Pomegranates and Pomegranate Juice. They themselves are very potent anti-oxidants, and they can be metabolized into other compounds (ellagic acid, urolithins) that themselves have anti-oxidant capabilities (although lesser). This large anti-oxidant value of punicalagins, about thrice that of red wine and green tea, is what brought Pomegranates to fame. That being said, the overall amount of punicalagins that get into the bloodstream after oral ingestion is quite small (6% is the highest noted and was in rats, sometimes human studies don't even notice punicalagins in the blood). The ellagic acid and urolithins still confer a lot of health benefits, but their anti-oxidant capabilities are on par with green tea and red wine if not a bit less potent. There is a very high variation between individuals, and like daidzein (one of the soy isoflavones) it may be genetically dependent on what intestinal microflora one possesses.
Like green tea, pomegranate is also rich in polyphenolic flavonoids. The phenol punicalagin is responsible for more than 50% of the juice's potent antioxidant activity. It appears that pomegranate juice has higher levels of punicalagin because the rind is used in its production. In fact, there is actually more antioxidant activity from the tannins in the juice than there is in the fruit itself. A 2-year, single-center clinical trial was completed for 48 men with prostate cancer and a rising PSA level after either surgery or radiotherapy for the treatment of prostate cancer.

DescriptionPunicalagin (65995-63-3) is a polyphenolic compound isolated from pomegranates possessing antioxidant, anti-inflammatory, and antitumorigenic properties.1,2?It has been shown to reduce high glucose-induced neural tube defects by blocking cellular stress and caspase activation.3?Punicalagin prevented high-fat diet induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage via AMPK mediated modulation of mitochondria and phase II enzymes.4
UsesPunicalagin is a natural polyphenolic compound extracted from the fruit of Pomegranate and acts as an effective anti-inflammatory and anti-oxidant.
References1) Seeram?et al. (2005),?In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice; J. Nutr. Biochem.,?16?360 2) Adams?et al. (2006),?Pomegranate Juice, Total Pomegranate Ellagitannins, and Punicalagin Suppress Inflammatory Cell Signaling in Colon Cancer Cells; J. Agric. Food Chem.,?54?980 3) Zhong?et al. (2015),?Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects; Biochem. Biophys. Res. Commun.,?467?179 4) Cao?et al. (2015),?Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation; Sci. Rep.,?5?14014
Punicalagin Preparation Products And Raw materials
Tag:Punicalagin(65995-63-3) Related Product Information
L-Epicatechin (-)-EGCG-3''-O-ME Willow Bark Extract Isochlorogenic Acid B (-)-Epicatechin gallate Ellagic acid 3-[(2-METHYLBENZYL)OXY]BENZALDEHYDE Punicalagin [1,1':3',1'']TERPHENYL-2'-CARBOXYLIC ACID 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether BIPHENYL-2,2'-DICARBOXYLIC ACID DIMETHYL ESTER punicalin 4-Hydroxy-2,6-dimethylbenzoic acid 4-HYDROXY-2,6-DIMETHYL-BENZENEMETHANOL 3,3'-DIPHENYLBIPHENYL DIETHYL BIPHENYL 2,2'-DICARBOXYLATE 3-Acetoxy-o-toluic acid Diphenic acid