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| | 1-Trifluoromethyl-2,3,4,9-tetrahydro-1H-B-carboline Basic information |
| Product Name: | 1-Trifluoromethyl-2,3,4,9-tetrahydro-1H-B-carboline | | Synonyms: | -carboline;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carboline;1,2,3,4-Tetrahydro-1-(trifluoromethyl)-ß;1,2,3,4-Tetrahydro-1-(trifluoroMethyl)--carboline;1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole;1,2,3,4-TETRAHYDRO-1-(TRIFLUOROMETHYL)-BETA-CARBOLINE;(S)-1-Trichloromethyl-1,2,3,4-Tetrahydro-βrac 1-Trichloromethyl-1,2,3,4-Tetrahydro-&beta | | CAS: | 112037-78-2 | | MF: | C12H11F3N2 | | MW: | 240.22 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 112037-78-2.mol |  |
| | 1-Trifluoromethyl-2,3,4,9-tetrahydro-1H-B-carboline Chemical Properties |
| Melting point | 147-149°C | | Boiling point | 350.0±37.0 °C(Predicted) | | density | 1.351±0.06 g/cm3(Predicted) | | pka | 16.63±0.40(Predicted) |
| | 1-Trifluoromethyl-2,3,4,9-tetrahydro-1H-B-carboline Usage And Synthesis |
| Mechanism of action | Although βCCE and other β-carbolines are not endogenous BZR
ligands (vide supra) and are not currently approved for clinical use, they are used to characterize different
GABAA/BZR subtypes (based on a and g subunit composition) and function (e.g., the partial agonist abecarnil)
toward the discovery of anxioselective drugs. In this regard, the β-carboline ring system is planar in comparison
to the boat conformation of the 1,4-benzodiazepines; thus, β-carbolines
have been useful to extend structure–activity relationship information for the agonist, antagonist, and inverse
agonist pharmacophores of the various GABAA/BZR subtypes. | | Clinical Use | Several β-carbolines have approximately 10-fold higher affinity for the BZR when compared to diazepam. The ethyl
ester of β-carboline-3-carboxylic acid (βCCE), identified in human urine extracts as an artifact of the extraction
procedure, has very high affinity for the BZR. |
| | 1-Trifluoromethyl-2,3,4,9-tetrahydro-1H-B-carboline Preparation Products And Raw materials |
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