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2-BROMOHEXADECANOIC ACID

2-BROMOHEXADECANOIC ACID Suppliers list
Company Name: Apeloa production Co.,Limited
Tel: +8619933239880
Email: admin@apcl.com.cn
Products Intro: Product Name:2-bromohexadecanoic acid
CAS:18263-25-7
Purity:0.98 Package:1g;1USD
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:CAS18263-25-7 2-BROMOHEXADECANOIC ACID
CAS:18263-25-7
Purity:99% Package:25KG;5KG;1KG
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +8618530059196
Email: sale04@alfachem.cn
Products Intro: Product Name:2-BROMOHEXADECANOIC ACID
CAS:18263-25-7
Purity:95% Min. Package:5g, 10g, 100g; 500g; 1kg; 25kg
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:2-Bromohexadecanoic acid
CAS:18263-25-7
Purity:0.99, AD68
Company Name: sgtlifesciences pvt ltd
Tel: +8617013299288
Email: dj@sgtlifesciences.com
Products Intro: Product Name:2-Bromohexadecanoic acid
CAS:18263-25-7

2-BROMOHEXADECANOIC ACID manufacturers

2-BROMOHEXADECANOIC ACID Basic information
Product Name:2-BROMOHEXADECANOIC ACID
Synonyms:A-BROMOPALMITIC ACID;2-BROMOHEXADECANOIC ACID;2-bromo-hexadecanoicaci;2-BROMOHEXADECANOIC ACID (2-Bromopalmitic Acid);ALPHA-BROMOPALMITATE;Bromohexadecanoicacid;2-Bromohexadecanoic acid, 98 %;α-Bromopalmitic acid
CAS:18263-25-7
MF:C16H31BrO2
MW:335.32
EINECS:242-137-0
Product Categories:Bioactive Small Molecules;Building Blocks;C13 to C42+;Carbonyl Compounds;Carboxylic Acids;Cell Biology;Chemical Synthesis;Organic Building Blocks;B
Mol File:18263-25-7.mol
2-BROMOHEXADECANOIC ACID Structure
2-BROMOHEXADECANOIC ACID Chemical Properties
Melting point 52-54 °C
Boiling point 403.4±18.0 °C(Predicted)
density 1.1985 (rough estimate)
refractive index 1.4650 (estimate)
Fp 113 °C
storage temp. RT
solubility methanol: soluble1g/10 mL, clear, colorless
form solid
pka2.97±0.21(Predicted)
color White
BRN 1726517
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
CAS DataBase Reference18263-25-7(CAS DataBase Reference)
EPA Substance Registry SystemHexadecanoic acid, 2-bromo- (18263-25-7)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 2915907098
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
2-BROMOHEXADECANOIC ACID Usage And Synthesis
Description2-Bromopalmitic acid (18263-25-7) inhibits?protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential palmitoylation as a prerequisite for receptor signaling.2
Chemical PropertiesWHITE CRYSTALLINE POWDER
Uses2-Bromopalmitic Acid is used in preparation of substituted purines and their analogs for inhibiting the expression of a pattern recognition receptor.
DefinitionChEBI: A bromo fatty acid that is hexadecanoic (palmitic) acid carrying a single bromo substituent at position 2.
General DescriptionPPARδ (peroxisome proliferator-activated receptor, delta isoform) acts as a transcription factor for gene expression as well as playing a role in lipid metabolism regulation; activity of this receptor is ligand-regulated. 2-Bromohexadecanoic acid is a metabolically stable analoge of the fatty acid palmitic acid that has been shown to be a natural ligand for the PPARδ receptor. 2-Bromohexadecanoic acid has also been used in studies of fatty acid oxidation, palmitoylation, and glucose uptake.
Biochem/physiol Actions2-Bromohexadecanoic acid is a PPARδ agonist. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.
Purification MethodsRecrystallise the acid from pet ether (b 60-80o, charcoal) and finally from EtOH. The ethyl ester has b 177-178o/2mm, d28 1.0484, n D 1.4560. [IR: Sweet & Estes J Org Chem 21 1426 1956, Beilstein 2 IV 1184.]
References1) Tsukamoto et al. (2013), Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells; PLoS One, 8(9) e75831 2) Chen et al. (2017), Palmitoylation-dependent activation of MC1R prevents melanomagenesis; Nature, 549 399
2-BROMOHEXADECANOIC ACID Preparation Products And Raw materials
Preparation Products2-HYDROXYHEXADECANOIC ACID-->2-Aminohexadecanoic acid-->(1-carboxylatopentadecyl)trimethylammonium-->N-PENTADECYLPYRIDINIUM BROMIDE
Tag:2-BROMOHEXADECANOIC ACID(18263-25-7) Related Product Information
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