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| (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate Basic information |
Product Name: | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate | Synonyms: | 2-Azabicyclo[3.1.0]hexane-3-carboxaMide, (1S,3S,5S)-,MonoMethanesulfonate;2-Azabicyclo[3.1.0]hexane-3-carboxaMide, (1S,3S,5S)-, Methanesulfonate (1:1);(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxaMide MonoMethanesulfonate;(1S,3S,5S)-,MonoMethanesulfonate;(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide mesylate;(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxaMide Methanesulfonate;(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide.MSA salt;Saxaint-Q | CAS: | 709031-45-8 | MF: | C7H14N2O4S | MW: | 222.26 | EINECS: | 615-206-1 | Product Categories: | | Mol File: | 709031-45-8.mol | |
| (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate Chemical Properties |
density | 1.5g/cm3 at 20℃ | vapor pressure | 0-0Pa at 20-25℃ | storage temp. | Inert atmosphere,Room Temperature | form | Solid | LogP | -2.9--1.1 at 20℃ and pH7 | Surface tension | 74.4mN/m at 1g/L and 20℃ |
| (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate Usage And Synthesis |
Uses | (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate is a pharmaceutical intermediate compound used in the preparation of saxagliptin and its hydrochloride salt. saxagliptin is a DPP-4 inhibitor used in the treatment of type 2 diabetes mellitus. |
| (1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate Preparation Products And Raw materials |
Raw materials | Ethyl L-pyroglutamate-->(1S,3S,5S)-3-(Aminocarbonyl)-2-azabicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester-->1H-Pyrrole-1-carboxylic acid, 2-(aMinocarbonyl)-2,3-dihydro-, 1,1-diMethylethyl ester, (2S)--->(S)-1-Boc-2,3-dihydro-2-pyrrolecarboxylic acid ethyl ester-->1,2-Pyrrolidinedicarboxylic acid, 5-hydroxy-, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S)--->Methanesulfonic acid |
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