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Methanesulfonic acid

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Products Intro: Product Name:Metane Sulfonic Acid
CAS:75-75-2
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CAS:75-75-2
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CAS:75-75-2
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CAS:75-75-2
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Products Intro: Product Name:Methanesulfonic Acid
CAS:75-75-2
Purity:70%(Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

Methanesulfonic acid manufacturers

  • Methanesulfonic acid
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  • CAS:75-75-2
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  • Methanesulfonic acid
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  • 2022-01-11
  • CAS:75-75-2
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Related articles

  • What is Methanesulfonic acid?
  • Methanesulfonic acid appears as colorless or slightly brown oily liquid, appearing as solid at low temperatures.It also has st....
  • Apr 22,2021
Methanesulfonic acid Chemical Properties
Melting point 17-19 °C (lit.)
Boiling point 167 °C/10 mmHg (lit.)
density 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
vapor density 3.3 (vs air)
vapor pressure 1 mm Hg ( 20 °C)
refractive index n20/D 1.429(lit.)
Fp >230 °F
storage temp. 2-8°C
solubility water: soluble1,000 g/L at 20°C
pka-2.6(at 25℃)
form Solution
color brown
Specific Gravity1.48 (18/4℃)
Water Solubility Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
λmaxλ: 240-320 nm Amax: <0.4
Sensitive Light Sensitive & Hygroscopic
Merck 14,5954
BRN 1446024
Stability:Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals. Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKeyAFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference75-75-2(CAS DataBase Reference)
NIST Chemistry ReferenceCH3SO3H(75-75-2)
EPA Substance Registry SystemMethanesulfonic acid (75-75-2)
Safety Information
Hazard Codes C
Risk Statements 34-22-21/22-35
Safety Statements 26-36-45-1/2-36/37/39
RIDADR UN 3265 8/PG 2
WGK Germany 1
RTECS PB1140000
TSCA Yes
HazardClass 8
PackingGroup III
HS Code 29041000
Hazardous Substances Data75-75-2(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 649 mg/kg LD50 dermal Rabbit 200 - 2000 mg/kg
MSDS Information
ProviderLanguage
Alkanesulfonic acid English
SigmaAldrich English
ACROS English
ALFA English
Methanesulfonic acid Usage And Synthesis
descriptionMethanesulfonic acid (CH3SO3H, MSA) is a strong organic acid. The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. MSA undergoes biodegradation by forming CO2 and sulphate. It is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.The aqueous MSA solution has been considered a model electrolyte for electrochemical processes.
Methanesulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl. It has a role as an Escherichia coli metabolite. It is an alkanesulfonic acid and a one-carbon compound. It is a conjugate acid of a methanesulfonate.
Chemical propertiesMethanesulfonic acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures. It has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa),  the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃). It is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene. It will not subject to decomposition in boiling water and hot alkaline solution. It also has strong corrosion effect against the metal iron, copper and lead.
UsesMethanesulfonic acid is a raw material for medicine and pesticide. It can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
It can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry. It can also be applied to oxidation.
Production methodIt can be obtained through the nitrate oxidation of thiocyanate methyl. Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃. After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product. The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered. The filtrate is condensed to until crystalline precipitation. The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate. It is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product. Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction. The reaction solution was extracted with chloroform. After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure. Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride. Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear. The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.
Chemical PropertiesMethanesulfonic acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methanesulfonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations. Beyond that, methanesulfonic acid is used as a starting material for the preparation of methanesulfonyl chloride.
UsesPolymerization catalyst.
Methanesulfonic acid has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings. One of the major advantages of methanesulfonic acid over sulfuric acid is that it is not an oxidizing species.
Uses
For complete protein and peptide hydrolysis with tryptophan recovery. After hydrolysis the samples are diluted prior to amino acid analysis.
UsesMethanesulfonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. It is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. It reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. It finds application in batteries, because of its purity and chloride absence. In pharmaceutical industry, it is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. It is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.It is involved in the deprotection of peptides.
PreparationMethanesulfonic acid is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.
DefinitionChEBI: An alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
General Description
Methanesulfonic acid (MSA) is a strong organic acid. The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. MSA undergoes biodegradation by forming CO2 and sulphate. It is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.1 The aqueous MSA solution has been considered a model electrolyte for electrochemical processes.
HazardToxic by ingestion, skin irritant, corrosiveto tissue.
Safety ProfilePoison by ingestion and intraperitoneal routes. May be corrosive to skin, eyes, and mucous membranes. Explosive reaction with ethyl vinyl ether. Incompatible with hydrogen fluoride. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.
Purification MethodsDry the acid, either by azeotropic removal of water with *benzene or toluene, or by stirring 20g of P2O5 with 500mL of the acid at 100o for 0.5hours. Then distil it under vacuum and fractionally crystallise it by partial freezing. Sulfuric acid, if present, can be removed by prior addition of Ba(OH)2 to a dilute solution, filtering off the BaSO4 and concentrating under reduced pressure; and is sufficiently pure for most applications. [Beilstein 4 IV 10.]
Tag:Methanesulfonic acid(75-75-2) Related Product Information
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