- ML 161
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- $5.00 / 5KG
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2019-09-04
- CAS:423735-93-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1ton
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| Product Name: | ML 161 | | Synonyms: | ML 161;2-BroMo-N-[3-[(1-oxobutyl)aMino]phenyl]benzaMide;2-BroMo-N-(3-butyraMidophenyl)benzaMide;Benzamide, 2-bromo-N-[3-[(1-oxobutyl)amino]phenyl]-;ML 161 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide;ML161;ML-161;ML161, >=98%;Parmodulin 2 | | CAS: | 423735-93-7 | | MF: | C17H17BrN2O2 | | MW: | 361.23 | | EINECS: | 803-969-5 | | Product Categories: | Inhibitors | | Mol File: | 423735-93-7.mol |  |
| | ML 161 Chemical Properties |
| Boiling point | 465.7±30.0 °C(Predicted) | | density | 1.441±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL (clear solution) | | pka | 12.37±0.70(Predicted) | | form | powder | | color | white to beige |
| RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 |
| | ML 161 Usage And Synthesis |
| Description | ML-161 is an allosteric, reversible inhibitor of proteinase-activated receptor 1 (PAR1) on platelets, preventing surface expression of P-selectin induced by the peptide SFLLRN with an IC50 value of 0.26 μM. It blocks platelet activation induced by thrombin as well as by SFLLRN but not by PMA , U-46619 , or collagen. | | Uses | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. | | Uses | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet
activation. | | Definition | ChEBI: 2-bromo-N-[3-(1-oxobutylamino)phenyl]benzamide is a member of benzamides. | | references | [1]. dockendorff, c., et al., discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the par1 receptor. acs med chem lett, 2012. 3(3): p. 232-237.
[2]. verplank, l., et al., chemical genetic analysis of platelet granule secretion-probe 3, in probe reports from the nih molecular libraries program. 2010, national center for biotechnology information (us): bethesda (md). |
| | ML 161 Preparation Products And Raw materials |
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