细胞松弛素 B
| 中文名称 | 细胞松弛素 B |
|---|---|
| 中文同义词 | 细胞松弛素 B 来源于长蠕孢菌;细胞松弛素 B 来源于DRECHSLERA DEMATIOIDEA;CYTOCHALASIN B 细胞松弛素B;松胞素B;细胞分裂抑素B;细胞松驰素B;细胞松弛素B;细胞松弛素 B |
| 英文名称 | CYTOCHALASIN B |
| 英文同义词 | CytochalasinB from Drechslera dematioidea,Phomin;Cytochalasin B, froM Drechslera deMatoidea;Cytochalasin B (7S),(20R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E),21(E)-triene-1,23-dione;Cytochalasin B from Helminthosporium dematioideum;ec[2,3-d]isoindole-2,18(5h)-dione;(E,E)-16-BENZYL-6,7,8,9,10,12A,13,14,15,15A,16,17-DODECAHYDRO-5,13-DIHYDROXY-9,15-DIMETHYL-14-METHYLENE-2H-OXACYCLOTETRADE[2,3-D]ISOINDOLE-2,18(5H)-DIONE;CYTOCHALASIN B, HELMINTHOSPORIUM DEMATIOIDEUM;CYTOCHALASIN B |
| CAS号 | 14930-96-2 |
| 分子式 | C29H37NO5 |
| 分子量 | 479.61 |
| EINECS号 | 239-000-2 |
| 相关类别 | 抗生素;其他生化试剂;微生物代谢物;生化试剂;抗生素及抗病毒;医药原料药-科研原料;生物碱;医药原料;试剂盒-细胞分析试剂盒;标准品;酶类;antibiotic |
| Mol文件 | 14930-96-2.mol |
| 结构式 |  |
细胞松弛素 B 性质
| 熔点 | 218-223 °C |
|---|---|
| 沸点 | 577.96°C (rough estimate) |
| 密度 | 1.1490 (rough estimate) |
| 折射率 | 1.6290 (estimate) |
| 闪点 | 85℃ |
| 储存条件 | -20°C |
| 溶解度 | 乙醇：20 mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.60±0.70(Predicted) |
| 颜色 | 白色 |
| Merck | 13,2819 |
| BRN | 1096207 |
| 稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 1 个月。 |
| InChIKey | UXVDBQLLXVKPRS-UZBFCAAUSA-N |
| SMILES | C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O |
| LogP | 3.370 |
| EPA化学物质信息 | Cytochalasin B (14930-96-2) |
细胞松弛素B在细胞内同微丝的正端结合, 并引起F-肌动蛋白解聚，阻断亚基的进一步聚合。当将细胞松弛素加入到活细胞后，肌动蛋白纤维骨架消失，使动物细胞的各种活动瘫痪, 包括细胞的移动、吞噬作用、胞质分裂等。
Kd: 2.2 nM (F-actin, with Mg 2+ ), 1.4 nM (F-actin, with Mg 2+ /K + )
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with K d s of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl 2 (2 mM) or MgCl 2 (2 mM) plus KCl, respectively. Cytochalasin B (0.1-10 μM) shows inhibitory effect on multiple murine cancer cell lines, with IC 50 s of 2.56 μM (M109c), 10.46 μM (B16BL6), 105.5 μM (P388/ADR), 51.9 μM (P388/S) and IC 80 s of 12.23 μM (M109c), 44.86 μM (B16BL6), 188.4 μM (P388/ADR), 84.1 μM (P388/S) after treatment for 3 h, with IC 50 s of 0.25 μM (M109c), 0.37 μM (B16F10), 0.87 μM (B16BL6), and IC 80 s of 0.75 μM (M109c), 1.21 μM (B16F10), 10.41 μM (B16BL6) after treatment for 4 days. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments. In addition, Cytochalasin B accelerates the transformation from F-actin to G-actin, lowering the content of F-actin and significantly increasing G-actin bands during postmortem conditioning.
Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort.
安全信息
| 危险品标志 | T+,T |
|---|---|
| 危险类别码 | 26/27/28-63-23/24/25 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 1544 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS号 | RO0205000 |
| F | 10 |
| 危险等级 | 6.1(a) |
| 包装类别 | I |
| 海关编码 | 29349990 |
| 存储类别 | 6.1A - 可燃，急性毒性物质（类别1和类别2） 剧毒的危险物质 |
| 危险性类别 | 急性毒性 类别1 吸入 急性毒性 类别2 经皮 急性毒性 类别2 经口 生殖毒性 类别2 |
| 毒害物质数据 | 14930-96-2(Hazardous Substances Data) |
| 毒性 | LD50 intraperitoneal in mouse: 30mg/kg |
| 提供商 | 语言 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | 22809 | 细胞松弛素B Cytochalasin B | 14930-96-2 | 5mg | 2659元 |
| 2025/12/22 | HY-16928 | 细胞松弛素 B Cytochalasin B | 14930-96-2 | 1mg | 950元 |