| | 1-(3-Chlorphenyl)piperazine Basic information |
| | 1-(3-Chlorphenyl)piperazine Chemical Properties |
| Melting point | 210-214°C | | Boiling point | 105 °C | | density | 1.193 | | refractive index | 1,598-1,600 | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | Chloroform (Slightly), Methanol (Sparingly) | | form | Oil | | pka | 8.85±0.10(Predicted) | | color | Colourless to Orange | | LogP | 2.468 | | CAS DataBase Reference | 6640-24-0(CAS DataBase Reference) |
| | 1-(3-Chlorphenyl)piperazine Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow oily liquid | | Uses | It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone. | | Uses | It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone. | | Definition | ChEBI: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone. | | Hazard | A poison. |
| | 1-(3-Chlorphenyl)piperazine Preparation Products And Raw materials |
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