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4-HYDROXY-6-METHYLQUINAZOLINE

4-HYDROXY-6-METHYLQUINAZOLINE Suppliers list
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Products Intro: Product Name:4-HYDROXY-6-METHYLQUINAZOLINE
CAS:19181-53-4
Purity:90%-99.9% Package:1KG;3USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Email: linda@hubeijusheng.com
Products Intro: Product Name:4-HYDROXY-6-METHYLQUINAZOLINE
CAS:19181-53-4
Purity:0.99 Package:5KG;1KG
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:6-Methylquinazolin-4-ol
CAS:19181-53-4
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-63878
Company Name: Wuhan Chemwish Technology Co., Ltd
Tel: 027-67849912
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Products Intro: Product Name:6-methyl-4-quinazolinone
CAS:19181-53-4
Purity:0.98 Package:1g;5g;25g;1817g
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
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Products Intro: Product Name:4-HYDROXY-6-METHYLQUINAZOLINE
CAS:19181-53-4
Purity:98% 262 email:hanne@coreychem.com Package:1g;3.9USD

4-HYDROXY-6-METHYLQUINAZOLINE manufacturers

4-HYDROXY-6-METHYLQUINAZOLINE Basic information
Product Name:4-HYDROXY-6-METHYLQUINAZOLINE
Synonyms:4-HYDROXY-6-METHYLQUINAZOLINE;BUTTPARK 51\07-11;3,4-Dihydro-6-methyl-4-oxoquinazoline;3,4-Dihydro-6-methyl-4-oxoquinazoline 98%;4-Hydroxy-6-methylquinazoline 97%;4-Hydroxy-6-methylquinazoline97%;6-methyl-4-quinazolinone;6-methylquinazolin-4-ol
CAS:19181-53-4
MF:C9H8N2O
MW:160.17
EINECS:
Product Categories:blocks;Heterocycles;Quinolines
Mol File:19181-53-4.mol
4-HYDROXY-6-METHYLQUINAZOLINE Structure
4-HYDROXY-6-METHYLQUINAZOLINE Chemical Properties
Melting point 238-240
Boiling point 334.6±35.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka2.06±0.20(Predicted)
AppearanceWhite to off-white Solid
Safety Information
Hazard Codes Xi
Hazard Note Irritant
HS Code 2933399990
MSDS Information
4-HYDROXY-6-METHYLQUINAZOLINE Usage And Synthesis
Synthesis
2-AMINO-5-METHYLBENZAMIDE

40545-33-3

Trimethoxymethane

149-73-5

4-HYDROXY-6-METHYLQUINAZOLINE

19181-53-4

Concentrated hydrochloric acid (4.16 mL, 49.9 mmol) was slowly added to a mixed solution containing commercially available 2-amino-5-methylbenzamide (5.00 g, 33.3 mmol) and trimethyl orthoformate (51.0 mL, 466 mmol) at 0 °C. The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue obtained was diluted with distilled water and neutralized with 2 M aqueous sodium hydroxide solution to neutral. Subsequently, the precipitated solid product was collected by filtration and washed sequentially with distilled water, methanol, and ether to finally obtain 6-methyl-4-hydroxyquinazoline (15) as a white powdery solid (4.33 g, 81% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 2.44 (3H, s), 7.57 (1H, d, J = 8.4 Hz), 7.62-7.66 (1H, m), 7.91-7.93 (1H, m), 8.03 (1H, s), 12.2 (1H, bs).

References[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5487 - 5505
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 545 - 548
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 383 - 391
Tag:4-HYDROXY-6-METHYLQUINAZOLINE(19181-53-4) Related Product Information
Nolatrexed dihydrochloride 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE 4-HYDROXY-6-METHYLQUINAZOLINE 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE Raltitrexed 8-METHYL-4-QUINAZOLONE 4-Hydroxy-2-methylquinazoline 8-Chloro-2-methylquinazolin-4(3H)-one NU1025 6-Quinazolinecarboxylic acid, 3,4-dihydro-3-(2-chlorophenyl)-5,7-dimet hyl-2-((((methylamino)carbonyl)oxy)methyl)-4-oxo-, ethyl ester (6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID Doqualast 3-(2,4-DICHLORO-5-METHOXYPHENYL)-6-METHYL-2-SULFANYL-4(3H)-QUINAZOLINONE (3-ETHYL-6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID 3-amino-2-(4-chlorophenyl)-6-methyl-4(3H)-quinazolinone (3-ALLYL-6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID 3-(4-FLUOROPHENYL)-2,6-DIMETHYL-4(3H)-QUINAZOLINONE (6-METHYL-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID

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