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8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt manufacturers
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| | 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Basic information |
| Product Name: | 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt | | Synonyms: | 8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-5-quinolinesulfonic acid disodium;NAPHTHYLAZOXINE S DISODIUM SALT;8-Hydroxy-7-[(6-sulfo-2-naphthalenyl)-azo]-5-quinolinesulfonic acid disodiu;8-HYDROXY-7-(6-SULFO-2-NAPHTHYLAZO)-5- QUINOLINESULFONIC ACID DISODIUM SALT 98%;8-Hydroxy-7-(6-sodiooxysulfonyl-2-naphtylazo)quinoline-5-sulfonic acid sodium salt;8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt,98%;5-Quinolinesulfonicacid,8-hydroxy-7-[(6-sulfo-2-naphthalenyl)azo]-,disodiumsalt;7-(6-Sulfo-2-naphthylazo)-8-hydroxyquinoline-5-sulfonicacid,disodiumsalt | | CAS: | 56932-43-5 | | MF: | C19H11N3Na2O7S2 | | MW: | 503.42 | | EINECS: | 260-449-5 | | Product Categories: | | | Mol File: | 56932-43-5.mol |  |
| | 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Chemical Properties |
| Safety Statements | 24/25 | | WGK Germany | WGK 2 | | TSCA | TSCA listed | | Storage Class | 11 - Combustible Solids |
| Provider | Language |
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ACROS
| English |
| | 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Usage And Synthesis |
| Chemical Properties | dark red to red-brown powder | | Uses | NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. | | Biological Activity | Cell permeable: yes', 'Primary Target
SHP1/2 PTPase', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively | | in vivo | NSC-87877 (30mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
| Animal Model: | Intrarenal neuroblastoma (NB) tumor mouse model in female nude mice[3].
| | Dosage: | 30mg/kg. | | Administration: | IP once daily for 15 days. | | Result: | Significantly inhibited NB tumor growth. |
| | References | [1] Chen L, et al. Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol Pharmacol. 2006 Aug;70(2):562-70. DOI:10.1124/mol.106.025536
[2] Song M, et al. NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5. DOI:10.1016/j.bbrc.2009.02.069
[3] Y Shi, et al. NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis. Cell Death Dis. 2015 Aug 6;6(8):e1841. DOI:10.1038/cddis.2015.207 |
| | 8-Hydroxy-7-(6-sulfo-2-naphthylazo)-5-quinolinesulfonic acid disodium salt Preparation Products And Raw materials |
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