N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide

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N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide manufacturers

  • SB228357
  • SB228357 pictures
  • $41.00
  • 2026-07-27
  • CAS:181629-93-6
  • Purity: 99.82%
  • Supply Ability: 10g
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide Basic information
Product Name:N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
Synonyms:SB 228357;N-[3-Fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide;N-[3-fluoro-5-(3-pyridinyl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide;1H-Indole-1-carboxamide, N-[3-fluoro-5-(3-pyridinyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-;SB-228357,SB228357;SB228357, 10 mM in DMSO;N-(3-Fluoro-5-(pyridin-3-yl)phenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide;N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide
CAS:181629-93-6
MF:C22H17F4N3O2
MW:431.38
EINECS:
Product Categories:
Mol File:181629-93-6.mol
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide Structure
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide Chemical Properties
Boiling point 625.4±55.0 °C(Predicted)
density 1.398±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~8 mg/mL, soluble
form solid
pka9.72±0.70(Predicted)
color white
Safety Information
Safety Statements 22-24/25
WGK Germany 3
MSDS Information
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SigmaAldrich English
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide Usage And Synthesis
UsesSB 228357 is a SR-2C/SR-2B receptor antagonist. It is used in the treatment of irritable bowel syndrome (IBS).
DefinitionChEBI: SB 228357 is an indolyl carboxylic acid.
Biological Activity5-HT 2C/2B receptor antagonist (pK i values are 7.0, 8.1 and 9.1 at 5-HT 2A , 2B and 2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT 2C receptor function. Orally active in vivo .
in vivo

SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2].

Animal Model:Male Sprague Dawley rats (200-250g) injected with Haloperidol[2]
Dosage:0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg
Administration: Oral administration; for 90 minutes
Result:Significantly reversed Haloperidol-induced catalepsy.
IC 505-HT2A Receptor: 6.9 (pKi); 5-HT2C Receptor: 9 (pKi); 5-HT2B Receptor: 8 (pKi)
storageStore at RT
N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide Preparation Products And Raw materials
Tag:N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide(181629-93-6) Related Product Information
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