| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 18918157536; |
| Email: |
sales8178@energy-chemical.com |
2-Methylglutaric acid manufacturers
- 2-methylglutaric acid
-
- $100.00
-
2023-07-04
- CAS:18069-17-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 500t/month
|
| | 2-Methylglutaric acid Chemical Properties |
| Melting point | 80-82 °C(lit.) | | Boiling point | 214-215 °C22 mm Hg(lit.) | | density | 1.4528 (rough estimate) | | refractive index | 1.4336 (estimate) | | Fp | 214-215°C/22mm | | form | powder | | BRN | 1723219 | | InChI | 1S/C6H10O4/c1-4(6(9)10)2-3-5(7)8/h4H,2-3H2,1H3,(H,7,8)(H,9,10) | | InChIKey | AQYCMVICBNBXNA-UHFFFAOYSA-N | | SMILES | CC(CCC(O)=O)C(O)=O | | CAS DataBase Reference | 18069-17-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29171990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Methylglutaric acid Usage And Synthesis |
| Preparation | Step 1: 80g diethyl malonate + 50mL DMF + 14g KF/Al2O3, oil bath 80℃, 50g methyl methacrylate dissolved in 50mL DMF was added dropwise, reaction for 5 hours. After the reaction, GC-MS analysis showed that most of the diethyl malonate was converted, and the chromatographic integral area percentage of the main intermediate was 56%. The solvents DMF and methanol were removed by vacuum distillation, and approximately 70g of product 1 was obtained by vacuum distillation at 160℃. Step 2: 0.1mol of product 1 was hydrolyzed with 0.4mol NaOH at 20℃ for 3 hours, then acidified with 0.4mol sulfuric acid, refluxed at 100℃ for decarboxylation for 4 hours, cooled, separated, and the aqueous phase was extracted with ethyl acetate 5 times. The organic phases were combined, the solvent was removed by vacuum, and GC-MS analysis showed that it was 2-methylglutaric acid (product 2). The chromatographic integral area percentage was 68%, and the yield was 60%. | | Chemical Properties | white to almost white fine crystalline powder | | Uses | 2-Methylglutaric acid was used in the preparation of acetic acid. | | Definition | ChEBI: 2-methylglutaric acid is an alpha,omega-dicarboxylic acid that is glutaric acid substituted at position 2 by a methyl group. It has a role as a mammalian metabolite. It is an alpha,omega-dicarboxylic acid and a dicarboxylic fatty acid. It is functionally related to a glutaric acid. It is a conjugate acid of a 2-methylglutarate(2-). | | Purification Methods | Crystallise the acid from distilled water, then dry it under vacuum over conc H2SO4. [Beilstein 2 IV 1989.] |
| | 2-Methylglutaric acid Preparation Products And Raw materials |
|