假尿苷
| 中文名称 | 假尿苷 |
|---|---|
| 中文同义词 | 5-Β-D-核呋喃基尿嘧啶;Β-假尿苷;假尿苷;Β-PSEUDOURIDINE;PSEUDOURIDINE 假尿苷;假鸟苷;尿苷杂质1;假尿苷三磷酸四锂盐溶液 |
| 英文名称 | Pseudouridine |
| 英文同义词 | 5-b-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione;5-β-D-ribofuranosyluracil;BETA-PSEUDOURIDINE;B-Pseudouridine;5-β-D-Ribofuranosyl-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-β-D-Ribofuranosylpyrimidine-2,4(1H,3H)-dione;Pseudouridine C;NSC 162405 |
| CAS号 | 1445-07-4 |
| 分子式 | C9H12N2O6 |
| 分子量 | 244.2 |
| EINECS号 | |
| 相关类别 | 核苷;修饰性核苷;化学试剂;医用原料;生化试剂;医药原料;医药、农药及染料中间体;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Pharmaceutical;常用糖合成中间体;有机化合物;核糖核苷酸;API/中间体;修饰核苷类 |
| Mol文件 | 1445-07-4.mol |
| 结构式 |  |
假尿苷 性质
| 熔点 | 222 °C |
|---|---|
| 密度 | 1.641±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | 甲醇（微溶，加热），水（微溶，超声处理，加热） |
| 酸度系数(pKa) | 8.52±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| PH值 | ~9.0 |
| 生物来源 | synthetic (chemical) |
| 水溶解性 | water: soluble |
| 最大波长(λmax) | 264nm(MeOH)(lit.) |
| InChI | InChI=1/C9H12N2O6/c12-2-4-5(13)6(14)7(17-4)3-1-10-9(16)11-8(3)15/h1,4-7,12-14H,2H2,(H2,10,11,15,16)/t4-,5-,6-,7+/s3 |
| InChIKey | PTJWIQPHWPFNBW-IZFRNLNUNA-N |
| SMILES | O[C@@H]1[C@@H]([C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O)O |&1:1,2,3,7,r| |
Pseudouridine，非编码 RNA 中最丰富的修饰核苷，通过稳定 RNA 结构增强转移 RNA 和核糖体 RNA 的功能。
|
Human Endogenous Metabolite
|
用途
An isomer of the nucleoside uridine found in all species and in many classes of RNA except mRNA. It is formed by enzymes called synthases, which post-transcriptionally isomerize specific uridine res idues in RNA in a process termed pseudouridylation. Studies suggest that β-Pseudouridine reduces radiation-induced chromosome aberrations in human lymphocytes.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海关编码 | 2934.99.9001 |
| 存储类别 | 13 - 不可燃性固体 |