(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone

(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone Basic information

Product Name:	(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone
Synonyms:	(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone;SDI-118
CAS:	1651179-19-9
MF:	C13H10ClF3N4O
MW:	330.69
EINECS:
Product Categories:
Mol File:	1651179-19-9.mol

(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone Chemical Properties

Boiling point	504.2±60.0 °C(Predicted)
density	1.63±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka	-0.07±0.50(Predicted)
form	Solid
color	Off-white to light yellow

Safety Information

MSDS Information

(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone Usage And Synthesis

Uses	SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC50 of 13 nM[1].
References	[1] Botermans W, et al., SDI-118, a novel procognitive SV2A modulator: First-in-human randomized controlled trial including PET/fMRI assessment of target engagement. Front Pharmacol. 2023 Jan 17;13:1066447. DOI:10.3389/fphar.2022.1066447

(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone Preparation Products And Raw materials

Tag:(4R)-1-[(5-Chloro-1H-1,2,4-triazol-1-yl)methyl]-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone(1651179-19-9) Related Product Information

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