PST-2744
| 中文名称 | PST-2744 |
|---|---|
| 中文同义词 | 化合物 T15600 |
| 英文名称 | Istaroxime |
| 英文同义词 | Istaroxime;PST 2744;PST2744;PST-2744;PST2744/PST-2744;CS-1089;Istaroxime(PST2744);(3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione |
| CAS号 | 203737-93-3 |
| 分子式 | C21H32N2O3 |
| 分子量 | 360.5 |
| EINECS号 | |
| 相关类别 | 膜转运/离子通道;离子通道;膜转运;医药原料;贝尔卡主打 |
| Mol文件 | 203737-93-3.mol |
| 结构式 |  |
PST-2744 性质
| 沸点 | 511.1±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.34±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于H2O |
| 形态 | 粉末 |
| 酸度系数(pKa) | 9.49±0.10(Predicted) |
IC50: 0.11 μM (Na + ,K + -ATPase)
Istaroxime acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
Istaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg.