5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER manufacturers
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| | 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Basic information |
| Product Name: | 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER | | Synonyms: | 5-Chlor-4-nitro-2-thiophencarbonsaeureMethylester;5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;AKOS 91745;Methyl 5-chloro-4-nitro-2-thiophenecarboxylate;5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER, 95+%;2-Thiophenecarboxylic acid, 5-chloro-4-nitro-, methyl ester;Methyl 5-chloro-4-nitrothiophene-2-carboxylate;Ethyl 5-chloro-4-nitrothiophene-2-carboxylate | | CAS: | 57800-76-7 | | MF: | C6H4ClNO4S | | MW: | 221.62 | | EINECS: | | | Product Categories: | API intermediates | | Mol File: | 57800-76-7.mol |  |
| | 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Chemical Properties |
| Melting point | 83-84 °C | | Boiling point | 349.3±37.0 °C(Predicted) | | density | 1.576±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | Appearance | White to light brown Solid |
| | 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Usage And Synthesis |
| Synthesis | Step 2: Preparation of methyl 5-chloro-4-nitrothiophene-2-carboxylate
Fuming nitric acid (15 mL) was placed in an ice bath and cooled with saturated brine. Methyl 5-chlorothiophene-2-carboxylate (4.99 g, 28.3 mmol) was added slowly in small batches to avoid violent reaction. After addition, the reaction mixture was stirred in an ice bath for 1 hour. Upon completion of the reaction, the mixture was poured into ice water and a solid was precipitated. The precipitate was collected by filtration, washed with water and dried under vacuum to afford methyl 5-chloro-4-nitrothiophene-2-carboxylate (3.88 g, 58% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 8.17 (1H, s). | | References | [1] Patent: EP1688420, 2006, A1. Location in patent: Page/Page column 122
[2] Patent: CN107903208, 2018, A. Location in patent: Paragraph 0136; 0137; 0139
[3] Journal of the American Chemical Society, 1952, vol. 74, p. 2965,2969 |
| | 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials |
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