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| | Spectinomycin sulfate tetrahydrate Basic information |
| Product Name: | Spectinomycin sulfate tetrahydrate | | Synonyms: | SPECTINOMYCINHCL;Actinospectacin, tetrahydrate, sulfate;Spectinomycin, tetrahydrate, sulfate;Trobicin sulfate;SpectinoMycin sulfate tetrahydrate CGMP/FDA;Spectinomycin sulfate tetrahydrate;U-18409E;U 18409E, ANTIBIOTIC | | CAS: | 64058-48-6 | | MF: | C14H26N2O11S | | MW: | 430.43 | | EINECS: | 613-422-0 | | Product Categories: | API | | Mol File: | 64058-48-6.mol |  |
| | Spectinomycin sulfate tetrahydrate Chemical Properties |
| Melting point | ~185° (dec) | | alpha | D25 +17.0° (c = 1 in water) | | storage temp. | -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Water (Slightly) | | pka | pKa1 7.00, pKa2 8.75(at 25℃) | | color | White |
| | Spectinomycin sulfate tetrahydrate Usage And Synthesis |
| Uses | Spectinomycin Sulfate Tetrahydrate (cas# 64058-48-6) is a compound useful in organic synthesis. | | in vivo | Spectinomycin dihydrochloride pentahydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks[4].
Spectinomycin dihydrochloride pentahydrate (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form[5].
Pharmacokinetics of Spectinomycin dihydrochloride pentahydrate in Rat[5]
| Parameter | C0 (μg/mL) | AUC0-∞ (μgh/mL) | Vd (L/kg) | CL (L/h/kg) | MRT (h) | T1/2α (h) | T1/2β (h) | T1/2γ (h) | fe | CLrenal (L/h/kg) | Eratio | | Non atrioventricular analysis | 44.3 | 16.8 | 0.756 | 0.602 | 0.757 | / | / | / | 0.553 | 0.359 | 1.00 | | Three-compartment model | 37.8 | 15.7 | 0.747 | 0.649 | 1.11 | / | 0.237 | 0.754 | 19.5 | / | / |
| Animal Model: | Arbor Acres plus broiler chicks (15-day-old)[4] | | Dosage: | 20 mg/kg, 60 mg/kg, 100 mg/kg | | Administration: | Intramuscular injection (chest muscles); 9 days | | Result: | Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).
Resulted minor toxicity of 60 mg/kg.
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| | Spectinomycin sulfate tetrahydrate Preparation Products And Raw materials |
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