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Dimethyl sulfate

Dimethyl sulfate Suppliers list
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Dimethyl sulfate
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Products Intro: Product Name:Dimethyl sulfate
Purity:98+% Package:25g;50g;100g;500g;1kg;10kg;50kg
Company Name: Haihang Industry Co.,Ltd
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Products Intro: Product Name:Dimethylsulfate
Company Name: Shanghai Song Yuan Chemical Technology Co., Ltd.  Gold
Tel: 18521000990
Products Intro: CAS:77-78-1
Company Name: Nanjing Huang Tai Pharmaceutical Technology Co. Ltd.  Gold
Tel: 18551845925QQ3569572487
Products Intro: Product Name:Dimethyl sulfate
Dimethyl sulfate Basic information
Description References
Product Name:Dimethyl sulfate
Product Categories:Pharmaceutical Intermediates;Miscellaneous Reagents, Sulfur & Selenium Compounds
Mol File:77-78-1.mol
Dimethyl sulfate Structure
Dimethyl sulfate Chemical Properties
Melting point -32 °C
Boiling point 188 °C(lit.)
density 1.333 g/mL at 25 °C(lit.)
vapor density 4.3 (vs air)
vapor pressure 0.7 mm Hg ( 25 °C)
refractive index n20/D 1.386(lit.)
Fp 182 °F
storage temp. 2-8°C
solubility ethanol: 0.26 g/mL, clear, colorless
form Liquid
color Clear colorless
OdorAlmost odorless
Water Solubility 2.8 g/100 mL (18 ºC)
Merck 13,3282
BRN 635994
Stability:Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS DataBase Reference77-78-1(CAS DataBase Reference)
NIST Chemistry ReferenceSulfuric acid, dimethyl ester(77-78-1)
EPA Substance Registry SystemSulfuric acid, dimethyl ester(77-78-1)
Safety Information
Hazard Codes T+
Risk Statements 45-25-26-34-43-68
Safety Statements 53-45-61
RIDADR UN 1595 6.1/PG 1
WGK Germany 2
RTECS WS8225000
Autoignition Temperature495 °C
HazardClass 6.1(a)
PackingGroup I
Hazardous Substances Data77-78-1(Hazardous Substances Data)
ToxicityLD50 orally in rats: 440 mg/kg (Smyth)
MSDS Information
Dimethyl sulfate English
SigmaAldrich English
Dimethyl sulfate Usage And Synthesis
DescriptionDimethyl sulfate (chemical formula: (CH3O)2SO2) is an odorless, corrosive, oily liquid which can release toxic fumes during heating. It can be synthesized through the esterification of sulfuric acid with methanol, and alternatively by the distillation of methyl hydrogen sulfate. In industry, dimethyl sulfate is used as a methylating agent for the manufacture of many organic chemicals. It can be used for methylation of phenols, amines, and thiol. Moreover, it can be used for base sequencing and DNA chain cleavage since it can rupture the imidazole rings present in guanine. It can also be used for protein-DNA interaction analysis. However, its vapor is toxic to eyes and lungs, can do harm to our body. It is a potential carcinogen based on known experimental data.
Chemical Propertiescolourless liquid
UsesDimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions
DefinitionChEBI: The dimethyl ester of sulfuric acid.
UsesMethylating agent in the manufacture of many organic chemicals. War gas.
General DescriptionDimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.
Air & Water ReactionsWater soluble.
Reactivity ProfilePure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].
Health HazardAcute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities.
Health HazardDimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.
Fire HazardFlash Point (°F): 240 ℃; 182 ℃; Flammable Limits in Air (%): Data not available; Fire Extinguishing Agents: Water, foam, carbon dioxide, or dry chemical; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Flammable, toxic vapors generated; Behavior in Fire: Not pertinent; Ignition Temperature (°F): 370; Electrical Hazard: Not pertinent; Burning Rate: Data not available.
Fire HazardMaterial is normally stable even under fire exposure conditions and is not hazardously reactive with water. Dimethyl sulfate is incompatible with strong oxidizers and strong ammonia solutions.
Fire HazardDimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.
Chemical ReactivityReactivity with Water Slow, non-hazardous reaction; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Sodium bicarbonate or lime; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety ProfileConfirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.
storagework with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.
IncompatibilitiesDimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.
Flammability and ExplosibilityDimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.
Waste DisposalExcess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.
Tag:Dimethyl sulfate(77-78-1) Related Product Information
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