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KW-2478

KW-2478 更多供应商
公司名称: 上海波以尔化工有限公司  
联系电话:
产品介绍: 英文名称:KW-2478
CAS:819812-04-9
公司名称: 上海景颜化工科技有限公司  
联系电话: 13817811078,021-50426030
产品介绍: 英文名称:KW-2478
纯度:98%
公司名称: 武汉永璨生物科技有限公司  
联系电话: 027-65522453
产品介绍: 英文名称:KW-2478
CAS:819812-04-9
纯度:98% HPLC 包装信息:50.0mg;100.0mg; 200.0mg;500mg;1g;5g; 10g 备注:科研试剂
公司名称: 济南精合医药科技有限公司  
联系电话: +86 (531) 88811783
产品介绍: 英文名称:KW-2478
CAS:819812-04-9
纯度:99% 包装信息:5Mg, 10Mg, 20Mg, 50Mg
公司名称: BOC Sciences  
联系电话: 16316197922
产品介绍: 英文名称:KW-2478
CAS:819812-04-9
KW-2478
生物活性体外研究体内研究
中文名称:KW-2478
中文同义词:2-乙基-3,5-二羟基-N,N-双(2-甲氧基乙基)-6-[3-甲氧基-4-[2-(4-吗啉基)乙氧基]苯甲酰基]苯乙酰胺;2-(2-乙基-3,5-二羟基-6-(3-甲氧基-4-(2-吗啉代乙氧基)苯甲酰基)苯基)-N,N-双(2-甲氧基乙基)乙酰胺
英文名称:KW-2478
英文同义词:KW-2478;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide;2-(2-ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxyethyl)acetamide;2-Ethyl-3,5-dihydroxy-N,N-bis(2-methoxyethyl)-6-[3-methoxy-4-[2-(4-morpholinyl)ethoxy]benzoyl]benzeneacetamide KW2478;2-(2-Ethyl-3,5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N,N-bis(2-methoxye;CS-287;2-[2-ethyl-3,5-dihydroxy-6-[3-methoxy-4-(2-morpholin-4-ylethoxy)benzoyl]phenyl]-N,N-bis(2-methoxyethyl)acetamide;KW2478; KW-2478; KW 2478.
CAS号:819812-04-9
分子式:C30H42N2O9
分子量:574.66248
EINECS号:
相关类别:细胞骨架信号;Inhibitor
Mol文件:819812-04-9.mol
KW-2478
KW-2478 性质
密度 1.209
KW-2478 用途与合成方法
生物活性KW-2478是一种非Ansamycin的HSP90抑制剂,IC50为3.8 nM。Phase 1。
体外研究KW-2478 inhibits the binding of bRD to Hsp90α with IC50 of 3.8 nM. KW-2478 degradates the Hsp90 client proteins, including FGFR3 and IGF-1Rβand c-Raf-1. KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity. KW-2478 downregulates the translocation products of IgH locus. KW-2478 inhibits the transcription of c-Maf and cyclin D1 genes by mainly suppressing the function of Cdk9. KW-2478 has potent and broad growth inhibitory activities against various cell lines, KW-2478 inhibites cancer cell growth in all cell lines, with EC50 of 101-252 nM, 81.4-91.4 nM and 120-622 nM for B-cell lymphoma, mantle cell lymphoma and multiple myeloma, respectively. KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively. .
体内研究KW-2478 suppresses tumor growth and induces the degradation of client proteins in tumors in NCI-H929 s.c. inoculated model at doses of 100 mg/kg or more. KW-2478 reduces both serum M protein and MM tumor burden in the bone marrow in OPM-2/GFP i.v. inoculated mouse model at doses of 100 mg/kg.
安全信息
"KW-2478" 相关产品信息()
BIIB021/CNF2024 SNX-5422 SNX-2112;4-(6,6-DIMETHYL-4-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)-2-((1R,4R)-4-HYDROXYCYCLOHEXYLAMINO)BENZAMIDE 阿螺旋霉素盐酸盐 NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE 替拉替尼