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(S)-MEPHENYTOIN

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Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427
Email: sales@conier.com
Products Intro: Product Name:(S)-MEPHENYTOIN
CAS:70989-04-7
Purity:99% Package:1kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(S)-Mephenytoin
CAS:70989-04-7
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
Tel: +undefined18051384581
Email: sales@chemhifuture.com
Products Intro: Product Name:(S)-MEPHENYTOIN
CAS:70989-04-7
Purity:98% HPLC Package:10mg，500mg，1g，5g，10g
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490
Email: info@gihichemicals.com
Products Intro: Product Name:(S)-Mephenytoin
CAS:70989-04-7
Purity:99 Package:5KG;1KG,25kg
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525
Email: masar@topule.com
Products Intro: Product Name:(S)-(+)-Mephenytoin
CAS:70989-04-7
Purity:98%+ Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
(S)-MEPHENYTOIN Basic information
Product Name:(S)-MEPHENYTOIN
Synonyms:(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin;(5S)-5-Ethyl-3-methyl-5-phenylhydantoin;(5S)-5β-Ethyl-3-methyl-5-phenylhydantoin;Mephenitoin S;(5S)-5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione;(5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione;(S)-(+)-MEPHENYTOIN;(S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE
CAS:70989-04-7
MF:C12H14N2O2
MW:218.25
EINECS:
Product Categories:Hydantoins and Derivatives;Hydantoins & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles
Mol File:70989-04-7.mol
(S)-MEPHENYTOIN Structure
(S)-MEPHENYTOIN Chemical Properties
Melting point 135-138 °C
density 1.154±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble
form solid
pka8.07±0.70(Predicted)
color off-white
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 2
HS Code 29332100
MSDS Information
ProviderLanguage
SigmaAldrich English
(S)-MEPHENYTOIN Usage And Synthesis
Chemical PropertiesWhite Crystalline Solid
UsesS-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).
Uses(S)-Mephenytoin can be used as an anticonvulsant agent.
DefinitionChEBI: (S)-Mephenytoin is an imidazolidine-2,4-dione.
Biological Activity(s)-mephenytoin is an anticonvulsive drug which is metabolized by n-demethylation and 4-hydroxylation (of the aromatic ring). (s)-mephenytoin is a substrate of the cytochrome p450 (cyp) isoform cyp2c19, also known as mephenytoin 4-hydroxylase [1].cyp2c19 is the main mephenytoin 4-hydroxylase in humans implicated in metabolizing a variety of therapeutic agents, such as omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates [2].
Biochem/physiol ActionsCYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.
in vitroin the presence of cytochrome b5, the km value for s-mephenytoin was 1.25 mm with all five purified cytochrome p-450s preparations, and vmax values were 0.8-1.25 nmol of 4-hydroxy product formed per min/nmol of p-450 [1].
references[1] shimada t, misono k s, guengerich f p. human liver microsomal cytochrome p-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. purification and characterization of two similar forms involved in the reaction[j]. journal of biological chemistry, 1986, 261(2): 909-921.
[2] ferguson r j, de morais s m f, benhamou s, et al. a new genetic defect in human cyp2c19: mutation of the initiation codon is responsible for poor metabolism of s-mephenytoin[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 356-361.
(S)-MEPHENYTOIN Preparation Products And Raw materials
Tag:(S)-MEPHENYTOIN(70989-04-7) Related Product Information
4-HYDROXY MEPHENYTOIN 4-HYDROXY MEPHENYTOIN-D3 (R)-MEPHENYTOIN,(R)-(-)-MEPHENYTOIN (S)-MEPHENYTOIN H-PHG-NH2 HCL (S)-MEPHENYTOIN,(S)-(+)-MEPHENYTOIN,MEPHENYTOIN,(+/-)-MEPHENYTOIN,DL-Mephenytoin 2-PHENYLBUTYRYLUREA 7,8-DIHYDROXY-6-METHOXYCOUMARIN 5-Phenylhydantoin S-(+)-N-Desmethyl Mephenytoin (S)-(+)-N-3-Benzylnirvanol 1,2-Ethanediamine,N2,N2-dimethyl-1-phenyl-,(1S)-(9CI) rac N-Desmethyl Mephenytoin-deuterated,rac N-Desmethyl Mephenytoin-D5 (Major) RAC MEPHENYTOIN-D3 N-DESMETHYL MEPHENYTOIN-D5 DESMETHYL MEPHENYTOIN,rac N-Desmethyl Mephenytoin rac Mephenytoin-D5 MEPHENYTOIN USP(CRM STANDARD)