3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 CAS#: 1449240-68-9

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐

生物活性靶点体外研究体内研究用途与合成方法 MSDS 3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐价格(试剂级) 上下游产品信息

中文名称	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐
中文同义词	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐;SPHK2抑制剂(K145盐酸盐);K145盐酸盐;3-(2-氨乙基)-5-(3-(4-丁氧基苯基)丙亚基)噻唑烷-2,4-二酮盐酸盐
英文名称	K145 (hydrochloride)
英文同义词	K145 (hydrochloride);K145(HCl);3-(2-Aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-2,4-thiazolidinedione hydrochloride (1:1);3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride;K14 (hydrochloride);SphK2 inhibitor;SPHK2 INHIBITOR;K 145 HYDROCHLORIDE;K-145 HYDROCHLORIDE;K145 hydrochloride >=98% (HPLC)
CAS号	1449240-68-9
分子式	C18H25ClN2O3S
分子量	384.9207
EINECS号
相关类别	细胞生物学试剂;API
Mol文件	1449240-68-9.mol
结构式

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐性质

储存条件	2-8°C
溶解度	在DMSO中的溶解度为20mg/mL，澄清
形态	粉末
颜色	白色至米色

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐用途与合成方法

生物活性

K145 hydrochloride 是一种选择性的，具有底物竞争性和口服活性的 SphK2 抑制剂，IC50 为 4.3 µM，Ki 为 6.4 µM。K145 hydrochloride 对 SphK1 和其他蛋白激酶没有活性。K145 hydrochloride 可诱导细胞凋亡，并具有强大的抗肿瘤活性。

靶点

IC50: 4.3 µM (SphK2)
Ki: 6.4 µM (SphK2)

体外研究

K145 (0-10 µM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner.
K145 (10 µM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells.
K145 (4-8 µM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt.
Treatment with K145 (10 µM) causes a decrease of total cellular S1P without significant effects on ceramide levels.

Cell Viability Assay

Cell Line:	U937 cells
Concentration:	0 µM, 4 µM, 6 µM, 8 µM, 10 µM
Incubation Time:	24 hours, 48 hours, 72 hours
Result:	Significantly inhibited the growth of U937 cells in a concentration-dependent manner.

Apoptosis Analysis

Cell Line:	U937 cells
Concentration:	10 µM
Incubation Time:	24 hours
Result:	Significantly induced apoptosis in U937 cells.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	4 µM, 8 µM
Incubation Time:	3 hours
Result:	Phosphorylated ERK and Akt were decreased.

体内研究

K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice.

Animal Model:	BALB/c-nu mice injected with U937 cells
Dosage:	50 mg/kg
Administration:	Oral gavage; daily; for 15 days
Result:	Inhibited the growth of U937 tumors at 50 mg/kg dose and no apparent toxicity was observed.

安全信息

WGK Germany	3

MSDS信息

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride	1449240-68-9	5mg	660元
2024/01/25	HY-15779A	3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐 K145 hydrochloride	1449240-68-9	10mM * 1mLin DMSO	726元

3-(2-氨基乙基)-5-[3-(4-丁氧基苯基)亚丙基]-2,4-噻唑烷二酮盐酸盐